Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6PCM1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
JHDM2A | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | Jhdm2a expression is induced by beta-adrenergic stimulation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Jhdm2a is critically important in regulating the expression of metabolic genes. The loss of Jhdm2a function results in obesity and hyperlipidemia in mice. The loss of Jhdm2a function disrupts beta-adrenergic-stimulated glycerol release and oxygen consumption in brown fat, and decreases fat oxidation and glycerol release in skeletal muscles. Jhdm2a directly regulates peroxisome proliferator-activated receptor alpha (Ppara) and Ucp1 expression. beta-Adrenergic activation-induced binding of Jhdm2a to the PPAR responsive element (PPRE) of the Ucp1 gene decreases levels of H3K9me2 (dimethylation of lysine 9 of histone H3) at the PPRE | Mus musculus |