Any feedback?
Literature summary for 1.14.11.65 extracted from
- Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia (2019), Int. J. Biochem. Cell Biol., 109, 33-39 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | JMJD1A is regulated by hypoxia-inducible factor HIF-2alpha in HepG2 cells under hypoxia. Knockdown or overexpression of JMJD1A can decrease or increase erythropoietin expression, respectively. JMJD1 A can interact with HIF-2alpha to form a coactivator complex, which binds to the hypoxia response elements of erythropoietin and increases erythropoietin expression by catalyzing demethylation of H3K9me2, a transcription suppression marker | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
