Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair | Drosophila melanogaster | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9V333 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage | Drosophila melanogaster |