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Literature summary for 1.14.11.65 extracted from

  • Colmenares, S.U.; Swenson, J.M.; Langley, S.3.; Kennedy, C.; Costes, S.V.; Karpen, G.H.
    Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity (2017), Dev. Cell, 42, 156-169 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus KDM4A predominantly localizes to heterochromatin and regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair Drosophila melanogaster 5634
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9V333
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General Information

General Information Comment Organism
physiological function KDM4A regulates heterochromatin position-effect variegation, organization of repetitive DNAs, and DNA repair. KDM4A demethylase activity is dispensable for position-effect variegation. KDM4A enzymatic activity is required to relocate heterochromatic double-strand breaks outside the domain, and for organismal survival when DNA repair is compromised. DNA damage triggers KDM4A-dependent changes in the levels of H3K56me3. In heterochromatin, KDM4A loss alters H3K9me3 but not H3K36me3 levels and KDM4A is required for demethylation of H3K56me3 during DNA damage Drosophila melanogaster