Literature summary for 1.14.11.65 extracted from

Lockman, K.; Taylor, J.; Mack, C.
The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression (2007), Circ. Res., 101, e115-e123 .

Search for more literature for 1.14.11.65

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q63679	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C3H10T1/2 cell	-	Rattus norvegicus	-
smooth muscle cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
JMJD1A	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	Jmjd1a binds myocardin-related transcription factor-A, and the jumonjiC domain of Jmjd1a is sufficient to mediate this interaction. Overexpression of Jmjd1a in multipotential 10T1/2 cells decreases global levels of dimethyl H3K9, stimulates alpha-actin and SM22 promoters, and synergistically enhances MRTF-A- and myocardin-dependent transactivation. TGF-beta-mediated upregulation of smooth muscle cell differentiation marker gene expression in 10T1/2 cells is associated with decreased H3K9 dimethylation at the CArG-containing regions of the smooth muscle cell differentiation marker gene promoters. Knockdown of Jmjd1a in 10T1/2 cells and primary rat aortic smooth muscle cells attenuates TGF-beta-induced upregulation of endogenous smooth muscle myosin heavy chain expression concomitant with increased H3K9 dimethylation at the differentiation marker gene promoters	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)