Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.65 extracted from

  • Zhu, Z.; Wang, Y.; Li, X.; Wang, Y.; Xu, L.; Wang, X.; Sun, T.; Dong, X.; Chen, L.; Mao, H.; Yu, Y.; Li, J.; Chen, P.; Chen, C.
    PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis (2010), Cell Res., 20, 794-801 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
H247A complete loss of activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus PHF8 colocalizes with B23 and fibrillarin Homo sapiens 5730
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UPP1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2
-
Homo sapiens a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Synonyms

Synonyms Comment Organism
PHF8
-
Homo sapiens

General Information

General Information Comment Organism
physiological function PHF8 binds to the promoter region of the rDNA gene. Knockdown of PHF8 reduces the expression of rRNA, and overexpression results in upregulation of rRNA transcript. Concomitantly, H3K9me2 levels are elevated in the promoter region of the rDNA gene in PHF8 knockdown cells and significantly reduced upon overexpression of PHF8 Homo sapiens