Protein Variants | Comment | Organism |
---|---|---|
H247A | complete loss of activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleolus | PHF8 colocalizes with B23 and fibrillarin | Homo sapiens | 5730 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UPP1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | - |
Homo sapiens | a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHF8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PHF8 binds to the promoter region of the rDNA gene. Knockdown of PHF8 reduces the expression of rRNA, and overexpression results in upregulation of rRNA transcript. Concomitantly, H3K9me2 levels are elevated in the promoter region of the rDNA gene in PHF8 knockdown cells and significantly reduced upon overexpression of PHF8 | Homo sapiens |