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Literature summary for 1.14.11.65 extracted from

  • Liu, Z.; Chen, X.; Zhou, S.; Liao, L.; Jiang, R.; Xu, J.
    The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function (2015), Int. J. Biol. Sci., 11, 494-507 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Mus musculus 5634
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Organism

Organism UniProt Comment Textmining
Mus musculus Q6ZPY7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
 Mus musculus
-
oviduct
-
 Mus musculus
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uterus
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
Kdm3b
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 Mus musculus

General Information

General Information Comment Organism
physiological function Kdm3b knockout mice display restricted postnatal growth and female infertility. Kdm3b ablation decreases IGFBP-3 expressed in the kidney by 53% and significantly reduces IGFBP-3 in the blood, which causes an accelerated degradation of IGF-1 and a 36% decrease in circulating IGF-1 concentration. Knockout of Kdm3b in female mice causes irregular estrous cycles, decreases 45% of the ovulation capability and 47% of the fertilization rate, and reduces 44% of the uterine decidual response, which are accompanied with a more than 50% decrease in the circulating levels of the 17beta-estradiol, associated with significantly increased levels of H3K9me1/2/3 in the ovary and uterus Mus musculus