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Literature summary for 1.14.11.65 extracted from

  • Audonnet, L.; Shen, Y.; Zhou, D.
    JMJ24 antagonizes histone H3K9 demethylase IBM1/JMJ25 function and interacts with RNAi pathways for gene silencing (2017), Gene Expr. Patterns, 25-26, 1-7 .
    View publication on PubMed
Search for more literature for 1.14.11.65

Cloned(Commentary)

Cloned (Comment) Organism
gene jmj25, promoter-GUS fusion analysis and histochemical assay of GUS activity of wild-type and mutants Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information homozygous mutant ibm1-4 (SALK_035608) is identified by PCR-based genotyping. The jmj24/ibm1 double mutant is generated by crossing jmj24-3 to ibm1-4. jmj24-2 is in the Wassilewskija background, whereas jmj24-3 and ibm1-4 are in the Columbia background Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Arabidopsis thaliana
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 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Arabidopsis thaliana Col-0
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Arabidopsis thaliana overall reaction [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Arabidopsis thaliana
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Arabidopsis thaliana
-
 [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Arabidopsis thaliana Q9SSE9
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-
Arabidopsis thaliana Col-0 Q9SSE9
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana Col-0 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Arabidopsis thaliana [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
IBM1
-
 Arabidopsis thaliana
JMJ25
-
 Arabidopsis thaliana
jmjC histone demethylase
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction The jmj24-3 mutation can partially complement ibm1 for phenotypic and gene expression defects Arabidopsis thaliana
malfunction an enzyme mutation causes a very severe growth phenotype with a much reduced plant size Arabidopsis thaliana
physiological function dimethylation of histone H3 lysine 9 (H3K9me2) is a heterochromatic mark linked to DNA methylation and gene repression. Removal of H3K9me2 from gene bodies by the jmjC histone demethylase JMJ25 inhibits DNA methylation and derepresses gene expression. JmjC domain protein JMJ24 antagonizes histone H3K9 demethylase IBM1/JMJ25 function and interacts with RNAi pathways for gene silencing Arabidopsis thaliana