Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.65 extracted from

  • Choi, J.Y.; Jo, S.A.
    KDM7A histone demethylase mediates TNF-alpha-induced ICAM1 protein upregulation by modulating lysosomal activity (2016), Biochem. Biophys. Res. Commun., 478, 1355-1362 .
    View publication on PubMed
Search for more literature for 1.14.11.65

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM7A, quantitative RT-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of KDM7A by siRNA transfection Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6ZMT4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
KDM7A
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of KDM7A by a small interfering RNA reduces the ICAM1 protein level and leukocyte adhesion without an effect on ICAM1 mRNA expression. In contrast, a KDM1B knockdown does not affect TNF-alpha-induced ICAM1 expression. Lysosome inhibitors increase the TNF-alpha-induced ICAM1 protein level and restore KDM7A knockdown-induced downregulation of ICAM1. In contrast, the KDM7A knockdown has no effect on proteasome-mediated ICAM1 degradation, but knockdown of KDM7A enhances CHX-induced ICAM1 protein degradation Homo sapiens
physiological function histone demethylase KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation by modulating lysosomal activity. KDM7A-mediated ICAM1 protein upregulation is likely related to protein stability, not a histone-mediated epigenetic mechanism, role of KDM7A in ICAM1 protein stabilization via a lysosome-dependent pathway, overview Homo sapiens