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Literature summary for 1.14.11.63 extracted from

  • Cheng, Y.; Wang, Y.; Li, J.; Chang, I.; Wang, C.Y.
    A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival (2017), Oncotarget, 8, 1972-1982 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in head and neck squamous cell carcinoma, a read-through fusion gene JMJD7-PLA2G4B is present, splicing neighboring JMJD7 and phospholipase A2, group IVB (PLA2G4B) genes together. Ablation of JMJD7-PLA2G4B significantly inhibits proliferation of head and neck squamous cell carcinoma cells by promoting G1 cell cycle arrest and increased starvation-induced cell death compared to JMJD7-only knockdown head and neck squamous cell carcinoma cells. JMJD7-PLA2G4B modulates phosphorylation of protein kinase B to promote head and neck squamous cell carcinoma cell survival. JMJD7-PLA2G4B also regulates an E3 ligase S-phase kinase-associated protein 2 to control the cell cycle progression from G1 phase to S phase by inhibiting cyclin-dependent kinase inhibitor 1 and 1B expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P0C870
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-

Source Tissue

Source Tissue Comment Organism Textmining
head and neck squamous cell carcinoma cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
JMJD7
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 Homo sapiens