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Literature summary for 1.14.11.63 extracted from

  • Markolovic, S.; Zhuang, Q.; Wilkins, S.E.; Eaton, C.D.; Abboud, M.I.; Katz, M.J.; McNeil, H.E.; Lesniak, R.K.; Hall, C.; Struwe, W.B.; Konietzny, R.; Davis, S.; Yang, M.; Ge, W.; Benesch, J.L.P.; Kessler, B.M.; Ratcliffe, P.J.; Cockman, M.E.; Fischer, R.; Wappner, P.; Chowdhury, R.; Coleman, M.L.; Schofield, C.J.
    The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018), Nat. Chem. Biol., 14, 688-695 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.63

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in presence of Mn2+ and 2-oxoglutarate, to 2.2 A resolution. JMJD7 crystallizes as an oligomer with two or four molecules in each asymmetric unit Homo sapiens

Protein Variants

Protein Variants Comment Organism
H178A almost complete loss of activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [protein]-L-lysine + 2-oxoglutarate + O2 Drosophila melanogaster
-
 a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
-
 ?
additional information Drosophila melanogaster enzyme additionally displays slow Fe(II)-stimulated conversion of 2-oxoglutarate to succinate in the absence of a substrate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VU77
-
-
Homo sapiens P0C870 bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [protein]-L-lysine + 2-oxoglutarate + O2
-
 Drosophila melanogaster a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
-
 ?
additional information enzyme additionally displays slow Fe(II)-stimulated conversion of 2-oxoglutarate to succinate in the absence of a substrate Drosophila melanogaster ?
-
 ?
additional information enzyme additionally displays slow Fe(II)-stimulated conversion of 2-oxoglutarate to succinate in the absence of a substrate Homo sapiens ?
-
 ?
[protein]-L-lysine + 2-oxoglutarate + O2 substrate is Developmentally Regulated GTP Binding Protein 1 Homo sapiens [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
-
 ?
[protein]-L-lysine + 2-oxoglutarate + O2 substrate is Developmentally Regulated GTP Binding Protein 2 Homo sapiens [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JMJD7
-
 Drosophila melanogaster
JMJD7
-
 Homo sapiens
Jumonji domain-containing protein 7
-
 Drosophila melanogaster
Jumonji domain-containing protein 7
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme interacts with Developmentally Regulated GTP Binding Proteins 1 and 2, DRG1/2 Homo sapiens
physiological function knockdown of JMJD7 correlates with increased posterior wing compartment size, likely through an increase in cell size Drosophila melanogaster