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Literature summary for 1.14.11.6 extracted from
- Uracils uncoupling of the decarboxylation of alpha-ketoglutarate in the thymine 7-hydroxylase reaction of Neurospora crassa (1981), J. Biol. Chem., 256, 6098-6101.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | - |
Neurospora crassa |  |
| catalase | - |
Neurospora crassa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Uracil | non-competitive inhibitor | Neurospora crassa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
thymine | - |
Neurospora crassa | |
| 0.2 | - |
Uracil | - |
Neurospora crassa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Neurospora crassa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine + 2-oxoglutarate + O2 | Neurospora crassa | - |
5-hydroxymethyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | Neurospora crassa uc-1 | - |
5-hydroxymethyluracil + succinate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | - |
uc-1 | - |
| Neurospora crassa uc-1 | - |
uc-1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Neurospora crassa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminouracil + 2-oxoglutarate + O2 | - |
Neurospora crassa | ? + succinate + CO2 | - |
? | |
| 5-aminouracil + 2-oxoglutarate + O2 | - |
Neurospora crassa uc-1 | ? + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | - |
Neurospora crassa | 5-hydroxymethyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | - |
Neurospora crassa uc-1 | 5-hydroxymethyluracil + succinate + CO2 | - |
? | |
| uracil + 2-oxoglutarate + O2 | - |
Neurospora crassa | ? + succinate + CO2 | - |
? | |
| uracil + 2-oxoglutarate + O2 | - |
Neurospora crassa uc-1 | ? + succinate + CO2 | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
Uracil | - |
Neurospora crassa | |
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