Literature summary for 1.14.11.54 extracted from

Li, X.; Xiong, X.; Wang, K.; Wang, L.; Shu, X.; Ma, S.; Yi, C.
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome (2016), Nat. Chem. Biol., 12, 311-316.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N1-methyladenine in mRNA + 2-oxoglutarate + O2	N1-methyladenine is prevalent in Homo sapiens mRNA, which shows an N1-methyladenine/adenine ratio of about 0.02%. Methylation of adenine in mRNA is reversible by ALKBH3. Recombinant ALKBH3 protein has robust demethylation activity against a synthetic RNA substrate containing a sitespecifically incorporated m1A modification	Homo sapiens	adenine in mRNA + formaldehyde + succinate + CO2	-	?

General Information

General Information	Comment	Organism
physiological function	N1-methyladenine in mRNA can be reversed by ALKBH3. Adenine methylation responds dynamically to stimuli, and hundreds of stress-induced N1-methyladenine sites can be identified. Knockout and overexpression of ALKBH3 in HEK-293T cells leads to an increased or decreased N1-methyladenine/adenine ratio in mRNA, respectively	Homo sapiens

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Release 2023.1 (January 2023)