Literature summary for 1.14.11.54 extracted from

Tasaki, M.; Shimada, K.; Kimura, H.; Tsujikawa, K.; Konishi, N.
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer (2011), Br. J. Cancer, 104, 700-706.

Search for more literature for 1.14.11.54

Application

Application	Comment	Organism
medicine	human adenocarcinomas and squamous cell carcinomas of the lung show overexpression of Alkbh3 and the percentage of cells positive for Alkbh3 also correlates statistically to recurrence-free survival in adenocarcinoma. Knockdown of Alkbh3 by siRNA transfection induces expression of p21WAF1/Cip1 and p27Kip1 in the human lung adenocarcinoma cell line A-549, resulting in cell cycle arrest, senescence and strong suppression of cell growth in vitro. In vivo, peritoneal tumour growth and dissemination is inhibited in nude mice, previously inoculated with the A-549 cell line, by intraperitoneal injection of Alkbh3 siRNA plus atelocollagen	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96Q83	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ALKBH3	-	Homo sapiens
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	human adenocarcinomas and squamous cell carcinomas of the lung show overexpression of Alkbh3 and the percentage of cells positive for Alkbh3 also correlates statistically to recurrence-free survival in adenocarcinoma. Knockdown of Alkbh3 by siRNA transfection induces expression of p21WAF1/Cip1 and p27Kip1 in the human lung adenocarcinoma cell line A-549, resulting in cell cycle arrest, senescence and strong suppression of cell growth in vitro. In vivo, peritoneal tumour growth and dissemination is inhibited in nude mice, previously inoculated with the A-549 cell line, by intraperitoneal injection of Alkbh3 siRNA plus atelocollagen	Homo sapiens

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Release 2023.1 (January 2023)