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Literature summary for 1.14.11.53 extracted from
- Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia (2021), Mol. Ther. Nucleic Acids, 26, 458-472 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6P6C2 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric cancer cell | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6-methyladenine in ZNF333 mRNA + 2-oxoglutarate + O2 | - |
Homo sapiens | adenine in ZNF333 mRNA + formaldehyde + succinate + CO2 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkylation repair homolog protein 5 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ALKBH5 demethylates zinc finger protein ZNF333 mRNA, leading to enhanced ZNF333 expression by abolishing m6A-YTHDF2-dependent mRNA degradation. ALKBH5 activates CDX2 and downstream intestinal markers by targeting the ZNF333/CYLD axis and activating NF-kappaB signaling. p65, the key transcription factor of the canonical NF-kappaB pathway, enhances the transcription activity of ALKBH5 in the nucleus. ALKBH5 levels are positively correlated with ZNF333 and CDX2 levels in gastric intestinal metaplasia tissues | Homo sapiens |
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Release 2023.1 (January 2023)
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