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Literature summary for 1.14.11.53 extracted from

  • Niu, Y.; Lin, Z.; Wan, A.; Chen, H.; Liang, H.; Sun, L.; Wang, Y.; Li, X.; Xiong, X.F.; Wei, B.; Wu, X.; Wan, G.
    RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3 (2019), Mol. Cancer, 18, 46 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine FTO is up-regulated in human breast cancer. High level of FTO is significantly associated with lower survival rates in patients with breast cancer. FTO promotes breast cancer cell proliferation, colony formation and metastasis in vitro and in vivo. BNIP3, a pro-apoptosis gene, is a downstream target of FTO-mediated m6A modification. BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients. BNIP3 dramatically alleviates FTO-dependent tumor growth retardation and metastasis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9C0B1
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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 Homo sapiens
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