Literature summary for 1.14.11.53 extracted from

Zhang, J.; Guo, S.; Piao, H.; Wang, Y.; Wu, Y.; Meng, X.; Yang, D.; Zheng, Z.; Zhao, Y.
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1 (2019), J. Physiol. Biochem., 75, 379-389 .

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Application

Application	Comment	Organism
medicine	substrate NEAT1 is a potential binding long noncoding lncRNA of ALKBH5. NEAT1 is overexpressed in gastric cancer cells and tissue. Knockdown of NEAT1 significantly represses invasion and metastasis of gastric cancer cells. ALKBH5 affects the m6A level of NEAT1. The binding of ALKBH5 and NEAT1 influences the expression of EZH2 (a subunit of the polycomb repressive complex) and thus affects gastric cancer invasion and metastasis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6P6C2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BGC-823 cell	-	Homo sapiens	-
GES-1 cell	-	Homo sapiens	-
SGC-7901 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N6-methyladenine in NEAT1 + 2-oxoglutarate + O2	substrate i.e. nuclear paraspeckle assembly transcript 1	Homo sapiens	adenine in NEAT1 + formaldehyde + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ALKBH5	-	Homo sapiens
alkylation repair homolog protein 5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	substrate NEAT1 is a potential binding long noncoding lncRNA of ALKBH5. NEAT1 is overexpressed in gastric cancer cells and tissue. Knockdown of NEAT1 significantly represses invasion and metastasis of gastric cancer cells. ALKBH5 affects the m6A level of NEAT1. The binding of ALKBH5 and NEAT1 influences the expression of EZH2 (a subunit of the polycomb repressive complex) and thus affects gastric cancer invasion and metastasis	Homo sapiens

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Release 2023.1 (January 2023)