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Literature summary for 1.14.11.53 extracted from
- The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability (2021), FEBS Lett., 595, 2007-2014 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | D3ZKD3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| osteoblast | - |
Rattus norvegicus | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | ALKBH5 mRNA and protein expression are upregulated during osteoblast differentiation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ALKBH5 mRNA and protein expression are upregulated during osteoblast differentiation. ALKBH5 knockdown suppresses osteoblast differentiation, mineralization, and the expression of osteogenic biomarkers. ALKBH5 overexpression promotes osteogenesis. Knockdown of ALKBH5 significantly impaires the mRNA stability of the transcription factor Runx2 | Rattus norvegicus |
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