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Literature summary for 1.14.11.53 extracted from

  • Jiang, Z.X.; Wang, Y.N.; Li, Z.Y.; Dai, Z.H.; He, Y.; Chu, K.; Gu, J.Y.; Ji, Y.X.; Sun, N.X.; Yang, F.; Li, W.
    The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging (2021), Cell Death Dis., 12, 744 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9C0B1 isoform FTO
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Source Tissue

Source Tissue Comment Organism Textmining
COV434 cell
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 Homo sapiens
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granulosa cell of ovaries, N6-methyladenosine increases in granulosa cells of human aged ovaries , while FTO-knockdown granulosa cells show faster aging-related phenotypes Homo sapiens
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KGN cell
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 Homo sapiens
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ovary m6A demethylase FTO is downregulated and N6-methyladenosine increases in granulosa cells of human aged ovaries Homo sapiens
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General Information

General Information Comment Organism
physiological function FTO acts as a senescence-retarding protein via N6-methyladenosine, and transcription factor subunit FOS knockdown significantly alleviates the aging of FTO-knockdown granulosa cells. FTO-knockdown granulosa cells show faster aging-related phenotypes, and increased N6-methyladenosine levels are found in the FOS-mRNA 3'UTR Homo sapiens