Literature summary for 1.14.11.53 extracted from

Chen, W.; Zhang, L.; Zheng, G.; Fu, Y.; Ji, Q.; Liu, F.; Chen, H.; He, C.
Crystal structure of the RNA demethylase ALKBH5 from zebrafish (2014), FEBS Lett., 588, 892-898.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with manganese(II) and 2-oxoglutarate, sitting drop vapor diffusion method, using 0.2 M sodium iodide, pH 7.0, 20% (w/v) polyethylene glycol 3350	Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2	Danio rerio	-	adenine in mRNA + formaldehyde + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q08BA6	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography, MonoS column chromatography, and Superdex 200 gel filtration	Danio rerio

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2	-	Danio rerio	adenine in mRNA + formaldehyde + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ALKBH5	-	Danio rerio
m6A RNA demethylase	-	Danio rerio

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Release 2023.1 (January 2023)