Literature summary for 1.14.11.51 extracted from

Liu, Y.; Chen, Y.; Wang, Y.; Jiang, S.; Lin, W.; Wu, Y.; Li, Q.; Guo, Y.; Liu, W.; Yuan, Q.
DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling (2022), J. Biol. Chem., 298, 101499 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13686	bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18	-

Synonyms

Synonyms	Comment	Organism
ALKBH1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	knockdown of ALKBH1 inhibits adipogenic differentiation in both mesenchymal stem cells and 3T3-L1 preadipocytes, while overexpression of ALKBH1 leads to increased adipogenesis. Hypoxia-inducible factor HIF-1 signaling is a crucial downstream target of ALKBH1 activity. Depletion of ALKBH1 leads to hypermethylation of both HIF-1alpha and its downstream target GYS1	Homo sapiens

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Release 2023.1 (January 2023)