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Literature summary for 1.14.11.51 extracted from

  • Cai, G.P.; Liu, Y.L.; Luo, L.P.; Xiao, Y.; Jiang, T.J.; Yuan, J.; Wang, M.
    Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging (2022), Cell Prolif., 55, e13178 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus P0CB42
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
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 Mus musculus
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bone marrow stem cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function Alkbh1 expression in bone marrow mesenchymal stem cells declines during aging. Knockout of Alkbh1 promotes adipogenic differentiation of bone marrow mesenchymal stem cells while inhibits osteogenic differentiation. Bone marrow mesenchymal stem cells -specific Alkbh1 knockout mice exhibit reduced bone mass and increased marrow adiposity. Overexpression of Alkbh1 attenuates bone loss and marrow fat accumulation in aged mice Mus musculus