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Literature summary for 1.14.11.45 extracted from

  • Hibi, M.; Kawashima, T.; Yajima, H.; Smirnov, S.; Kodera, T.; Sugiyama, M.; Shimizu, S.; Yokozeki, K.; Ogawa, J.
    Enzymatic synthesis of chiral amino acid sulfoxides by Fe(II)/alpha-ketoglutarate-dependent dioxygenase (2013), Tetrahedron Asymmetry, 24, 990-994.
No PubMed abstract available
Search for more literature for 1.14.11.45

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Bacillus thuringiensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-isoleucine + 2-oxoglutarate + O2 Bacillus thuringiensis
-
 (2S,3R,4S)-4-hydroxy-L-isoleucine + succinate + CO2
-
 ?
L-isoleucine + 2-oxoglutarate + O2 Bacillus thuringiensis 2e2
-
 (2S,3R,4S)-4-hydroxy-L-isoleucine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus thuringiensis
-
-
-
Bacillus thuringiensis 2e2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-allyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis S-allyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
(S)-allyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis 2e2 S-allyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
(S)-ethyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis S-ethyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
(S)-ethyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis 2e2 S-ethyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
(S)-methyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis S-methyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
(S)-methyl-L-cysteine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis 2e2 S-methyl-L-cysteine (S)-sulfoxide + succinate + CO2
-
 ?
L-ethionine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis L-ethionine (S)-sulfoxide + succinate + CO2
-
 ?
L-ethionine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis 2e2 L-ethionine (S)-sulfoxide + succinate + CO2
-
 ?
L-isoleucine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis (2S,3R,4S)-4-hydroxy-L-isoleucine + succinate + CO2
-
 ?
L-isoleucine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis 2e2 (2S,3R,4S)-4-hydroxy-L-isoleucine + succinate + CO2
-
 ?
L-methionine + 2-oxoglutarate + O2
-
 Bacillus thuringiensis L-methionine (S)-sulfoxide + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Bacillus thuringiensis
isoleucine 4-hydroxylase
-
 Bacillus thuringiensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
-
 Bacillus thuringiensis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
20 28 the enzyme retains over 80% of its activity after 1 h incubation at 20-28°C Bacillus thuringiensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7
-
 Bacillus thuringiensis

pH Stability

pH Stability pH Stability Maximum Comment Organism
7 9 the enzyme retains over 90% activity after 1 h of incubation at pH 7.0-9.0 Bacillus thuringiensis