Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.4 extracted from

  • Neyazi, B.; Tanrikulu, L.; Wilkens, L.; Hartmann, C.; Stein, K.P.; Dumitru, C.A.; Sandalcioglu, I.E.
    Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size (2017), World Neurosurg., 102, 79-84 .
    View publication on PubMed
Search for more literature for 1.14.11.4

Cloned(Commentary)

Cloned (Comment) Organism
gene PLOD2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Homo sapiens
-
brain PLOD2 is mainly expressed within the tunica media of the blood vessels Homo sapiens
-
additional information PLOD2 expression determination by immunhistochemic analysis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
lysylhydroxylase 2
-
 Homo sapiens
PLOD2
-
 Homo sapiens
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, PLOD2, is involved in the posttranscriptional modification of collagen molecules and considered as a key mediator of collagen cross-linking and thus an important factor for the stability of the extracellular matrix. PLOD2 is known to be associated with several connective tissue diseases, such as Ehlers-Danlos syndrome type VI A, systemic sclerosis, and Bruck syndrome. Isozyme PLOD2 is involved in the pathology of brain arteriovenous malformations (bAVM), severe conditions that can cause severe neurologic deficits and mortality. High levels of PLOD2 expression correlate with bAVM size. Although PLOD2 is not directly associated with bAVM hemorrhage, high PLOD2-expressing bAVM have a lower frequency of hemorrhage compared with low or medium PLOD2-expressing bAVM (25% vs. 63% and 75%, respectively) Homo sapiens