Literature summary for 1.14.11.4 extracted from

Gjaltema, R.A.; de Rond, S.; Rots, M.G.; Bank, R.A.
Procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor beta-1 activation mechanism (2015), J. Biol. Chem., 290, 28465-28476 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene PLOD2, binding of the TGFbeta1 pathway related transcription factors SMAD3 and SP1-mediated TGFbeta1 enhanced PLOD2 expression and might be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter. Depletion of SMAD3 reduces gene PLOD2 acetylated H3 and H4, histone methylation marks at the PLOD2 promoter depicted an increase of the active histone mark H3K79me2, a decrease of the repressive H4K20me3 mark, but no role for the generally strong transcription-related modifications: H3K4me3, H3K9me3 and H3K27me3. TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications. Quantitative real-time PCR enzyme expression analysis	Homo sapiens

Cloned (Comment)

Organism

gene PLOD2, binding of the TGFbeta1 pathway related transcription factors SMAD3 and SP1-mediated TGFbeta1 enhanced PLOD2 expression and might be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter. Depletion of SMAD3 reduces gene PLOD2 acetylated H3 and H4, histone methylation marks at the PLOD2 promoter depicted an increase of the active histone mark H3K79me2, a decrease of the repressive H4K20me3 mark, but no role for the generally strong transcription-related modifications: H3K4me3, H3K9me3 and H3K27me3. TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications. Quantitative real-time PCR enzyme expression analysis

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2	Homo sapiens	-	[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00469	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	skin	Homo sapiens	-
skin	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2	-	Homo sapiens	[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
2-oxoglutarate 5-dioxygenase 2	-	Homo sapiens
PLOD2	-	Homo sapiens
procollagen lysyl hydroxylase 2	-	Homo sapiens
procollagen-lysine	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	procollagen lysyl hydroxylase 2 expression is regulated by an alternative downstream transforming growth factor beta-1 activation mechanism. TGF-beta1 induces the enzyme, mechanism of TGFbeta1-enhanced PLOD2 expression, detailed overview	up

General Information

General Information	Comment	Organism
physiological function	the enzyme hydroxylates lysine residues in collagen telopeptides and is essential for collagen pyridinoline cross-link formation. PLOD2 expression and subsequent pyridinoline cross-links are increased in fibrotic pathologies by transforming growth factorbeta-1 (TGFbeta1). Binding of the TGFbeta1 pathway related transcription factors SMAD3 and SP1-mediated TGFbeta1 enhanced PLOD2 expression and might be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter	Homo sapiens