Literature summary for 1.14.11.30 extracted from

Chaplin, V.; Hangasky, J.; Huang, H.; Duan, R.; Maroney, M.; Knapp, M.
Chloride supports O2 activation in the D201G facial triad variant of factor-inhibiting hypoxia inducible factor, an alpha-ketoglutarate dependent oxygenase (2018), Inorg. Chem., 57, 12588-12595 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
formation of an Fe-Cl cofactor structure in variant D201G. The variant binds Fe with a His2Cl facial triad and activates O2 only in the presence of specific anions. A full His2X triad is an absolute requirement for O2 activation	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D201G	removal of the Asp ligand in the His2Asp facial triad, leads to a highly active enzyme. The variant supports anion dependent peptide hydroxylation, exogenous ligand binding to form a complete His2X facial triad is essential for O2 activation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NWT6	-	-

Synonyms

Synonyms	Comment	Organism
factor-inhibiting hypoxia inducible factor	-	Homo sapiens

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Release 2023.1 (January 2023)