Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | Drosophila melanogaster | hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | Caenorhabditis elegans | hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 | Drosophila melanogaster | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 | Caenorhabditis elegans | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hydroxylase domain enzyme | - |
Drosophila melanogaster |
hydroxylase domain enzyme | - |
Caenorhabditis elegans |
PHD | - |
Drosophila melanogaster |
PHD | - |
Caenorhabditis elegans |
prolyl 4-hydroxylase | - |
Drosophila melanogaster |
prolyl 4-hydroxylase | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
metabolism | isoforms PHD2 and 3 inhibit IkappaB kinase and decrease the activity of the nuclear factor-kappaB pathway. Isoform PHD2 also acts as a negative regulator of nuclear factor-kappaB during arteriogenesis | Drosophila melanogaster |
metabolism | isoforms PHD2 and 3 inhibit IkappaB kinase and decrease the activityof the nuclear factor-kappaB pathway. Isoform PHD2 also acts as a negative regulator of nuclear factor-kappaB during arteriogenesis | Caenorhabditis elegans |