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Literature summary for 1.14.11.28 extracted from

  • Shah, R.; Smith, P.; Purdie, C.; Quinlan, P.; Baker, L.; Aman, P.; Thompson, A.M.; Crook, T.
    The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer (2009), Br. J. Cancer, 100, 1687-1696.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
pharmacology the prolyl 3-hydroxylase P3H2 is a novel targets for epigenetic silencing in breast cancer Homo sapiens
pharmacology the prolyl 3-hydroxylase P3H3 is a novel targets for epigenetic silencing in breast cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q32P28 P3H2
-
Homo sapiens Q8IVL6 P3H3
-

Synonyms

Synonyms Comment Organism
Leprel1
-
 Homo sapiens
Leprel2
-
 Homo sapiens
P3H2
-
 Homo sapiens
P3H3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme expression of P3H2 and P3H3 is downregulated in breast cancer by abberrant CpG methylation in the 5'-regulatory sequences of each gene, methylation of P3H3 is not associated with higher tumour grade and Nottingham prognostic index down
Homo sapiens the enzyme expression of P3H2 is downregulated in breast cancer by abberrant CpG methylation in the 5'-regulatory sequences of each gene, methylation of P3H2 is specific for breast cancer and does not occur in other cancer cell types, it is strongly associated with higher tumour grade and Nottingham prognostic index down

General Information

General Information Comment Organism
physiological function P3H2 can function as a tumour suppressors in breast cancer Homo sapiens
physiological function P3H3 can function as a tumour suppressors in breast cancer Homo sapiens