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Literature summary for 1.14.11.27 extracted from

  • Pan, D.; Mao, C.; Zou, T.; Yao, A.Y.; Cooper, M.P.; Boyartchuk, V.; Wang, Y.X.
    The histone demethylase Jhdm1a regulates hepatic gluconeogenesis (2012), PLoS Genet., 8, e1002761.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.27

Cloned(Commentary)

Cloned (Comment) Organism
ectopic expression of either wild-type Jhdm1a or H212A point mutant in the liver of diabetic ob/ob mice Mus musculus
ectopic expression of Jhdm1a in HeLa and wild-type and enzyme-deficient Hep-G2 cells via lentivirus transfection Homo sapiens

Protein Variants

Protein Variants Comment Organism
H212A inactive mutant Mus musculus
additional information Jhdm1a knockdown or scramble adenoviruses are transduced into the liver of wild-type male C57BL/6J mice Mus musculus
additional information shRNA knockdown of Jhdm1a in Hep-G2 cells elevating gluconeogenic gene expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Mus musculus Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Mus musculus C57/BL6J Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 Mus musculus
-
 protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 Homo sapiens Jhdm1a actively demethylates dimethylated H3K36 on the C/EBPalpha locus protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 Mus musculus C57/BL6J
-
 protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
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hepatocyte primary Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Mus musculus histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 Mus musculus histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 Homo sapiens histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Mus musculus C57/BL6J histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 Mus musculus C57/BL6J histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2
-
 Mus musculus protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 Jhdm1a actively demethylates dimethylated H3K36 on the C/EBPalpha locus Homo sapiens protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?
protein C/EBPalpha-N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2
-
 Mus musculus C57/BL6J protein C/EBPalpha-N6-methyl-L-lysine + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K36 demethylase
-
 Mus musculus
H3K36 demethylase
-
 Homo sapiens
histone H3 lysine 36 demethylase
-
 Mus musculus
histone H3 lysine 36 demethylase
-
 Homo sapiens
JHDM1A
-
 Mus musculus
JHDM1A
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction Jhdm1a knockdown mice are still able to maintain normal glycemia, but display higher glucose production upon injection of the gluconeogenic substrate pyruvate Mus musculus
malfunction silencing of Jhdm1a promotes liver glucose synthesis, while its exogenous expression reduces blood glucose level in vivo Homo sapiens
additional information expression of the wild-type Jhdm1a, but not the H212A point mutant, decreased the expression of PEPCK and G6Pase in diabetic ob/ob mice Mus musculus
physiological function histone demethylase Jhdm1a regulates hepatic gluconeogenesis, regulation of gluconeogenesis by Jhdm1a requires its demethylation activity. Jhdm1a is a key negative regulator of gluconeogenic gene expression. Jhdm1a regulates the expression of a major gluconeogenic regulator, C/EBPalpha, by its USF1-dependent association with the C/EBPa promoter and its subsequent demethylation of dimethylated H3K36 on the C/EBPa lpha locus Homo sapiens
physiological function Jhdm1a has a physiological role in hepatic gluconeogenesis in vivo, and this role is mediated by its histone demethylation activity Mus musculus