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Literature summary for 1.14.11.2 extracted from

  • Huang, X.; Liu, X.; Song, J.; Wang, L.; Liu, X.; Qu, H.; Wang, S.; Zhang, C.; Zhang, Y.; Zhang, M.
    Prolyl-4-hydroxylase-alpha1 improves the stability of advanced plaques but accelerates the atherosclerotic lesion formation of early plaques (2015), Eur. Heart J., 17, C49-C58 .
No PubMed abstract available
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Application

Application Comment Organism
medicine P4Halpha1 overexpression might be a valuable therapeutic modality in stabilizing advanced but not early plaque because of the adverse event of accelerated lesion formation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene P4ha1 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q60715
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Source Tissue

Source Tissue Comment Organism Textmining
additional information analysis of P4Halpha1 expression during the pathological course of atherosclerotic plaque development, and effect of P4Ha1 overexpression on vulnerability of early and advanced plaque in apolipoprotein E-deficient (ApoE2/2) mice, overview Mus musculus
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Synonyms

Synonyms Comment Organism
P4Halpha1
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 Mus musculus
prolyl-4-hydroxylase-alpha1
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 Mus musculus

General Information

General Information Comment Organism
malfunction after 2 weeks of a treatment with lentivirus-mediated P4Halpha1 construct that is transfected in carotid plaque induced in mice (atherosclerotic plaques in ApoE-/- mice) by perivascular collar placement, both early and advanced plaque exhibit stable characteristics, with increased collagen and smooth muscle cell content, reduced macrophage content, and no change in lipid content. Lenti-P4Ha1 treatment of early and advanced plaque substantially increases interstitial collagen content in the fibrous cap of plaque. It increases the carotid plaque size and the relative en face lesion area of the aorta in early but not advanced plaque, with reduced phosphatase and tensin homologue expression. The treatment reduces the expression of inflammatory cytokines and the production and activity of matrix metalloproteinase-9 and -2 in both early and advanced plaque. P4Halpha1 overexpression has a differential effect at various stages of plaque pathological progression Mus musculus
physiological function prolyl-4-hydroxylase-alpha1 improves the stability of advanced plaques but accelerates the atherosclerotic lesion formation of early plaques. Analysis of P4Halpha1 expression during the pathological course of atherosclerotic plaque development, and effect of P4Ha1 overexpression on vulnerability of early and advanced plaque in apolipoprotein E-deficient (ApoE2/2) mice, overview Mus musculus