Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deferoxamine mesylate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
M10 cell | a melanoma cell line | Homo sapiens | - |
M14 cell | a melanoma cell line | Homo sapiens | - |
Mel120 cell | a melanoma cell line | Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
melanoma cell line | derived from primary melanoma | Homo sapiens | - |
SK-MEL-28 cell | a melanoma cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
prolyl hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | endothelin-1 inhibits PHD2 expression and promoter activity by 50% to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression | down |
General Information | Comment | Organism |
---|---|---|
additional information | Endothelin signalling implies HIF-alpha-dependent angiogenesis and tumor cell invasion through PHD2 inhibition in normoxic conditions. Endothelin-1 inhibits PHD2 expression and promoter activity to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression. Knockdown of PHD2 by inhibiting the prolyl hydroxylases with deferoxamine mesylate results in a strong induction of HIF-alpha and VEGF expression | Homo sapiens |