Protein Variants | Comment | Organism |
---|---|---|
H196R | inactive mutant | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
desferrioxamine | - |
Rattus norvegicus | |
dimethyl oxalylglycine | DMOG, the effect is HIF-independent | Rattus norvegicus | |
additional information | hypoxia inhibits the enzyme | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | EGLN3 contains a conserved iron-binding motif, of which two histidine residues, His135 and His196, are critical for its enzymatic activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
egg-laying abnormal-9 prolyl hydroxylase | - |
Rattus norvegicus |
EGLN prolyl hydroxylase | - |
Rattus norvegicus |
EGLN3 | - |
Rattus norvegicus |
EGLN3 hydroxylase | - |
Rattus norvegicus |
prolyl hydroxylase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | pharmacologic inactivation of EGLN3 hydroxylase results in activation of the canonical NF-kappaB pathway | Rattus norvegicus |
additional information | exogenous expression of wild-type EGLN3, but not of its catalytically inactive mutant, significantly inhibits NF-kappaB activation induced by overexpressed TRAF2 or IkappaB kinase 2, overview. Deletion of EGLN3 by small interfering RNAs leads to activation of NF-kappaB | Rattus norvegicus |
physiological function | egg-laying abnormal-9 prolyl hydroxylases regulate the stability and thereby the activity of the alpha-subunits of hypoxia-inducible factor through its ability to catalyze their hydroxylation. EGLN3 promotes differentiation of C2C12 skeletal myoblasts. EGLN3 is a negative regulator of NF-kappaB, and its prolyl hydroxylase activity is required for this effect. EGLN3 is involved in mediating myogenic differentiation, which is HIF-independent | Rattus norvegicus |