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Literature summary for 1.14.11.2 extracted from

  • Hussain, M.Z.; Ghani, Q.P.; Hunt, T.K.
    Inhibition of prolyl hydroxylase by poly(ADP-ribose) and phosphoribosyl-AMP. Possible role of ADP-ribosylation in intracellular prolyl hydroxylase regulation (1989), J. Biol. Chem., 264, 7850-7855.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Lactate stimulates, the activation of the enzyme in lactate-treated fibroblasts is correlated with a reduction in the total ADP-ribosylation Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
ADP-ribose weak inhibitor Gallus gallus
additional information the synthesis and degradation of ADP-ribose moieties may possibly regulate prolyl hydroxylase activity in vivo Gallus gallus
phosphoribosyl adenosine monophosphate 46% inhibition at 25 nM, 87% inhibition at 50 nM Gallus gallus
Poly(ADP-ribose) near complete inhibition at 6 nM, the effect is noncompetitive with respect to the binding of the cofactors ascorbate and alpha-ketoglutarate or of the substrate Gallus gallus
Ribosyl-ribosyl-adenine 43% inhibition at 25 nM, 85% inhibition at 50 nM Gallus gallus
Ribosyl-ribosyl-hypoxanthine 40% inhibition at 25 nM, 86% inhibition at 50 nM Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate precipitation, calcium phosphate batch fractionations and anion exchange chromatography on DEAE-agarose followed by gel filtration on agarose Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus gallus
-

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
Gallus gallus
ascorbate
-
Gallus gallus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000015
-
Poly(ADP-ribose)
-
Gallus gallus
0.0000162
-
phosphoribosyl adenosine monophosphate
-
Gallus gallus
0.0000162
-
Ribosyl-ribosyl-adenine
-
Gallus gallus