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Literature summary for 1.14.11.2 extracted from

  • Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Kaska, D.D.; Hanauske, A.; Kivirikko, K.I.
    Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines (1988), Biochem. J., 251, 365-372.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin activation Gallus gallus
bovine serum albumin activation Homo sapiens
catalase activation Gallus gallus
catalase activation Homo sapiens
dithiothreitol activation Gallus gallus
dithiothreitol activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
daunorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Gallus gallus
daunorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Homo sapiens
doxorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Gallus gallus
doxorubicin irreversible inhibitor, 50% inhibition after 1 h at 0.06 mM, effect dependent on the presence of iron ions Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Gallus gallus
Fe2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration Gallus gallus
using ammonium sulfate fractionation, affinity chromatography on poly(L-proline) coupled to Sepharose 4B, DEAE-cellulose chromatography, and gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Gallus gallus
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Gallus gallus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
(Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Homo sapiens (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Gallus gallus
37
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
 Gallus gallus
ascorbate
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.04
-
 doxorubicin competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate Gallus gallus
0.04
-
 doxorubicin competitive inhibitor with respect to 2-oxoglutarate, in concentrations not exceeding 0.02 mM, competitive inhibition is also found with respect to ascorbate Homo sapiens