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Literature summary for 1.14.11.16 extracted from

  • Brewitz, L.; Nakashima, Y.; Schofield, C.J.
    Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase (2020), Chem. Sci., 12, 1327-1342 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.16

Inhibitors

Inhibitors Comment Organism Structure
(1S,2S,4R)-3-oxalobicyclo[2.2.1]hept-5-ene-2-carboxylic acid
-
 Homo sapiens
1-oxalocyclopropane-1-carboxylic acid
-
 Homo sapiens
2,2-dimethyl-4-oxopentanedioic acid
-
 Homo sapiens
2-(2-methylpropyl)-4-oxopentanedioic acid
-
 Homo sapiens
2-(3,3-dimethylbutyl)-4-oxopentanedioic acid
-
 Homo sapiens
2-benzyl-4-oxopentanedioic acid
-
 Homo sapiens
2-ethyl-4-oxopentanedioic acid
-
 Homo sapiens
2-oxalocyclopropane-1-carboxylic acid
-
 Homo sapiens
2-oxo-3-(3-phenylpropyl)pentanedioic acid
-
 Homo sapiens
2-oxo-3-propylpentanedioic acid
-
 Homo sapiens
2-oxo-3-[[4-(trifluoromethoxy)phenyl]methyl]pentanedioic acid
-
 Homo sapiens
2-oxo-4-(3-phenylpropyl)pentanedioic acid
-
 Homo sapiens
2-oxo-4-propylpentanedioic acid
-
 Homo sapiens
2-[(naphthalen-2-yl)methyl]-4-oxopentanedioic acid
-
 Homo sapiens
3-(3,3-dimethylbutyl)-2-oxopentanedioic acid
-
 Homo sapiens
3-benzyl-2-oxopentanedioic acid
-
 Homo sapiens
3-ethyl-2-oxopentanedioic acid
-
 Homo sapiens
3-[(3,5-dimethylphenyl)methyl]-2-oxopentanedioic acid
-
 Homo sapiens
3-[(4-fluorophenyl)methyl]-2-oxopentanedioic acid
-
 Homo sapiens
3-[(4-methoxyphenyl)methyl]-2-oxopentanedioic acid
-
 Homo sapiens
5-oxalothiophene-2-carboxylic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12797
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
 pH 7.5, 20°C Homo sapiens 2-[(naphthalen-2-yl)methyl]-4-oxopentanedioic acid
0.00025
-
 pH 7.5, 20°C Homo sapiens 2-oxo-4-(3-phenylpropyl)pentanedioic acid
0.0003
-
 pH 7.5, 20°C Homo sapiens 2,2-dimethyl-4-oxopentanedioic acid
0.00043
-
 pH 7.5, 20°C Homo sapiens 2-benzyl-4-oxopentanedioic acid
0.00047
-
 pH 7.5, 20°C Homo sapiens 2-oxo-4-propylpentanedioic acid
0.00051
-
 pH 7.5, 20°C Homo sapiens 2-(2-methylpropyl)-4-oxopentanedioic acid
0.00052
-
 pH 7.5, 20°C Homo sapiens 2-oxalocyclopropane-1-carboxylic acid
0.00061
-
 pH 7.5, 20°C Homo sapiens 2-ethyl-4-oxopentanedioic acid
0.0007
-
 pH 7.5, 20°C Homo sapiens 2-(3,3-dimethylbutyl)-4-oxopentanedioic acid
0.0016
-
 pH 7.5, 20°C Homo sapiens 3-benzyl-2-oxopentanedioic acid
0.0026
-
 pH 7.5, 20°C Homo sapiens 3-[(4-fluorophenyl)methyl]-2-oxopentanedioic acid
0.0033
-
 pH 7.5, 20°C Homo sapiens 1-oxalocyclopropane-1-carboxylic acid
0.0036
-
 pH 7.5, 20°C Homo sapiens 3-[(4-methoxyphenyl)methyl]-2-oxopentanedioic acid
0.0047
-
 pH 7.5, 20°C Homo sapiens 3-[(3,5-dimethylphenyl)methyl]-2-oxopentanedioic acid
0.0057
-
 pH 7.5, 20°C Homo sapiens 2-oxo-3-propylpentanedioic acid
0.0063
-
 pH 7.5, 20°C Homo sapiens 2-oxo-3-[[4-(trifluoromethoxy)phenyl]methyl]pentanedioic acid
0.0068
-
 pH 7.5, 20°C Homo sapiens 2-oxo-3-(3-phenylpropyl)pentanedioic acid
0.012
-
 pH 7.5, 20°C Homo sapiens 3-ethyl-2-oxopentanedioic acid
0.0129
-
 pH 7.5, 20°C Homo sapiens 5-oxalothiophene-2-carboxylic acid
0.0193
-
 pH 7.5, 20°C Homo sapiens (1S,2S,4R)-3-oxalobicyclo[2.2.1]hept-5-ene-2-carboxylic acid
0.0482
-
 pH 7.5, 20°C Homo sapiens 3-(3,3-dimethylbutyl)-2-oxopentanedioic acid