Literature summary for 1.14.11.16 extracted from

Ma, M.; Hua, S.; Li, G.; Wang, S.; Cheng, X.; He, S.; Wu, P.; Chen, X.
Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma (2017), Oncotarget, 8, 12983-13002 .

Search for more literature for 1.14.11.16

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NWT6	cf. EC 1.14.11.30	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell line	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
asparaginyl hydroxylase factor inhibiting HIF-1	-	Homo sapiens
FIH	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	downregulation of asparaginyl hydroxylase factor inhibiting (FIH) in hepatocellular carcinoma is associated with more aggressive tumor behavior and a poor prognosis	down

General Information

General Information	Comment	Organism
drug target	downregulation of prolyl hydroxylase domain 3 and asparaginyl hydroxylase factor inhibiting (FIH) in hepatocellular carcinoma is associated with more aggressive tumor behavior and a poor prognosis. Both enzymes may be potential therapeutic targets for treatment of hepatocellular carcinoma	Homo sapiens
metabolism	hypoxia-inducible factors (HIFs) are key regulators in oxygen homeostasis. Their stabilization and activity are regulated by prolyl hydroxylase domain (PHD)-1, -2, -3 and asparaginyl hydroxylase factor inhibiting HIF-1 factor inhibiting HIF (FIH)	Homo sapiens
physiological function	hypoxia-inducible factors (HIFs) are key regulators in oxygen homeostasis. Their stabilization and activity are regulated by prolyl hydroxylase domain (PHD)-1, -2, -3 and asparaginyl hydroxylase factor inhibiting (FIH)	Homo sapiens

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Release 2023.1 (January 2023)