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Literature summary for 1.14.11.16 extracted from

  • Yang, H.; Wang, H.; Xue, T.; Xue, X.P.; Huyan, T.; Wang, W.; Song, K.
    Single-chain variable fragment antibody against human aspartyl/asparaginyl beta-hydroxylase expressed in recombinant Escherichia coli (2011), Hybridoma, 30, 69-79.
    View publication on PubMed
Search for more literature for 1.14.11.16

Inhibitors

Inhibitors Comment Organism Structure
additional information development of a ScFv anti-HAAH antibody for specific in vivo inhibition of the enzyme by expression of His-tagged light and heavy chain cloned from the hybridoma cells G3/F11 in Escherichia coli strain BL21(DE3)PlysS/pET-16b, partly in inclusion bodies, or of c-myc-tagged ScFv in Escherichia coli strain HB2151/pHEN1, partly cytosolic. Variable regions of the genes of the heavy chain and light chain are connected with a flexible linker using an overlap extension PCR. Nucleotide sequence analysis revealed that the anti-HAAH VH was a member of the VH V gene family and the VL gene belonged to the Vk gene family VI subgroup Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-associated Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme hydroxylates epidermal growth factor-like domains in transformation-associated proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
G3/F11 cell
-
 Homo sapiens
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additional information the enzyme is overexpressed in a wide variety of human malignancies such as breast, hepatic, biliary, colon, pulmonary, pancreatic, and neural origin Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme hydroxylates epidermal growth factor-like domains in transformation-associated proteins Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
aspartyl (asparaginyl) beta-hydroxylase
-
 Homo sapiens
aspartyl beta-hydroxylase
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 Homo sapiens
HAAH
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 Homo sapiens