Literature summary for 1.14.11.16 extracted from

Carter, J.J.; Tong, M.; Silbermann, E.; Lahousse, S.A.; Ding, F.F.; Longato, L.; Roper, N.; Wands, J.R.; de la Monte, S.M.
Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression (2008), Acta Neuropathol., 116, 303-315.

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Application

Application	Comment	Organism
medicine	insulin-like growth factor-1 stimulates peptide-aspartate beta-dioxygenase protein expression and directional motility. Ethanol reduces the stimulation without inhibition of the mRNA expression, and phosphorylation of the enzyme is higher in ethanol-treated compared with control cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Insulin-like growth factor-1	stimulates peptide-aspartate beta-dioxygenase protein expression and directional motility. Ethanol reduces the stimulation without inhibition of the mRNA expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	peptide-aspartate beta-dioxygenase can be phosphorylated by glycogen synthase kinase 3beta, and high levels of glycogen synthase kinase 3beta activity result in decrease in peptide-aspartate beta-dioxygenase protein, whereas inhibition of the kinase and/or global caspases increases peptide-aspartate beta-dioxygenase protein. Phosphorylation is higher in ethanol-treated compared with control cells	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
PNET-2 cell	cerebellar neuronal cell	Homo sapiens	-

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Release 2023.1 (January 2023)