Literature summary for 1.14.11.11 extracted from

Schlesinger, D.; Davidovich Rikanati, R.; Volis, S.; Faigenboim, A.; Vendramin, V.; Cattonaro, F.; Hooper, M.; Oren, E.; Taylor, M.; Sitrit, Y.; Inbar, M.; Lewinsohn, E.
Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6beta-hydroxylase gene (2019), Plant Sci., 283, 301-310 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-hyoscyamine + 2-oxoglutarate + O2	Mandragora autumnalis	-	(6S)-hydroxyhyoscyamine + succinate + CO	-	?

Organism

Organism	UniProt	Comment	Textmining
Mandragora autumnalis	A0A6M6R148	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-hyoscyamine + 2-oxoglutarate + O2	-	Mandragora autumnalis	(6S)-hydroxyhyoscyamine + succinate + CO	-	?
L-hyoscyamine + 2-oxoglutarate + O2	the bifunctional enzyme also catalyzes the conversion of (6S)-6beta-hydroxyhyoscyamine to scopolamine, cf. EC 1.14.20.13	Mandragora autumnalis	(6S)-hydroxyhyoscyamine + succinate + CO	-	?

Synonyms

Synonyms	Comment	Organism
H6H	-	Mandragora autumnalis
hyoscyamine 6beta-hydroxylase	-	Mandragora autumnalis

General Information

General Information	Comment	Organism
physiological function	the bifunctional enzyme catalyzes the last two steps in the scopolamine biosynthetic pathway: the hydroxylation of L-hyoscyamine to 6beta-hydroxyhyoscyamine (anisodamine) and its subsequent epoxidation to scopolamine	Mandragora autumnalis

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Release 2023.1 (January 2023)