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Literature summary for 1.14.11.1 extracted from

  • van Vlies, N.; Wanders, R.J.; Vaz, F.M.
    Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat (2006), Anal. Biochem., 354, 132-139.
    View publication on PubMed
Search for more literature for 1.14.11.1

Inhibitors

Inhibitors Comment Organism Structure
ZnCl2 1 mM, complete inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 4-Dimethylaminobutyric acid in 20mM potassium phosphate buffer (pH 7.4) containing 50 mM KCl, 3mM 2-oxoglutarate, 10 mM sodium ascorbate, 0.5 mM DTT, 0.5 mM ammonium iron sulfate, 2.5 mg/ml bovine serum albumin, 0.01% (w/v) Triton X-100 and 2 mM 6-N-trimethyllysine Mus musculus
0.063
-
 2-oxoglutarate in 20mM potassium phosphate buffer (pH 7.4) containing 50 mM KCl, 3mM 2-oxoglutarate, 10 mM sodium ascorbate, 0.5 mM DTT, 0.5 mM ammonium iron sulfate, 2.5 mg/ml bovine serum albumin, 0.01% (w/v) Triton X-100 and 2 mM 6-N-trimethyllysine Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ requires the presence of Fe2+ for optimal activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-dimethylaminobutyric acid + 2-oxoglutarate + O2
-
 Mus musculus 4-dimethylamino-3-hydroxybutyric acid + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
4-trimethylaminobutyric acid dioxygenase
-
 Mus musculus
gamma-BBD
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ascorbate requires the presence of ascorbate for optimal activity Mus musculus