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Literature summary for 1.13.99.1 extracted from

  • Gaut, J.P.; Crimmins, D.L.; Ohlendorf, M.F.; Lockwood, C.M.; Griest, T.A.; Brada, N.A.; Hoshi, M.; Sato, B.; Hotchkiss, R.S.; Jain, S.; Ladenson, J.H.
    Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury (2014), Clin. Chem., 60, 747-757 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.99.1

Application

Application Comment Organism
diagnostics the kidney-specific protein myo-inositol oxygenase is a potential biomarker of acute kidney injury, AKI Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene MIOX, kidney-specific expression, recombinant expression of GST-tagged enzyme in HEK-293 cells, cleavage of the GST tag by thrombin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myo-inositol + O2 Mus musculus
-
 D-glucuronate + H2O
-
 ?
myo-inositol + O2 Homo sapiens
-
 D-glucuronate + H2O
-
 ?
myo-inositol + O2 Mus musculus C57BL/6
-
 D-glucuronate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UGB7
-
-
Mus musculus Q9QXN5
-
-
Mus musculus C57BL/6 Q9QXN5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma from mice with acute kidney injury, MIOX expression is undetectable in healthy mice plasma Mus musculus
-
blood plasma plasma MIOX is increased in critically ill patients with acute kidney injury compared with patients without acute kidney injury and is highest in patients with oliguric acute kidney injury Homo sapiens
-
kidney kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule Mus musculus
-
kidney kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule Homo sapiens
-
additional information immunohistochemic analysis Mus musculus
-
additional information immunohistochemic analysis Homo sapiens
-
renal proximal tubule
-
 Mus musculus
-
renal proximal tubule
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myo-inositol + O2
-
 Mus musculus D-glucuronate + H2O
-
 ?
myo-inositol + O2
-
 Homo sapiens D-glucuronate + H2O
-
 ?
myo-inositol + O2
-
 Mus musculus C57BL/6 D-glucuronate + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 37000, recombinant detagged enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MIOX
-
 Mus musculus
MIOX
-
 Homo sapiens
Myo-inositol oxygenase
-
 Mus musculus
Myo-inositol oxygenase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function kidney-specific expression of myo-inositol oxygenase in acute kidney injury Mus musculus
physiological function MIOX is a renal specific, proximal tubule protein that is increased in plasma ofanimals and critically ill patients with acute kidney injury, AKI. MIOX preceds the elevation in SCr by approximately two days in human patients Homo sapiens