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Literature summary for 1.13.12.7 extracted from

  • Li, Y.; Jin, C.; Xu, H.; Wu, W.; Wang, Y.; Wu, J.; Liu, T.; Wan, G.; Yue, X.; Bu, X.
    Identification of 2-benzylidene-tetralone derivatives as highly potent and reversible firefly luciferase inhibitors (2022), ACS Med. Chem. Lett., 13, 304-311 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.12.7

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1-(1-benzofuran-2-yl)-3-(4-methylphenyl)prop-2-en-1-one
-
 Photinus pyralis
(2E)-1-(1-benzofuran-2-yl)-3-phenylprop-2-en-1-one
-
 Photinus pyralis
(2E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
-
 Photinus pyralis
(2E)-1-(5-chlorothiophen-2-yl)-3-(4-methylphenyl)prop-2-en-1-one
-
 Photinus pyralis
(2E)-1-(5-chlorothiophen-2-yl)-3-phenylprop-2-en-1-one
-
 Photinus pyralis
(2E)-2-benzylidene-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(2-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(2-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(2-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(2-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(2-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(3-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(3-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(3-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(3-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(3-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-ethoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-ethylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-fluorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-hydroxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(4-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[(pyridin-3-yl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(benzyloxy)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(diethylamino)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-7-methoxy-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-8-methoxy-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(methylsulfanyl)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-2-[[4-(trifluoromethyl)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-5-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-6-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-7-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(2E)-8-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
(6E)-6-[(3-carboxy-4-hydroxyphenyl)methylidene]-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
-
 Photinus pyralis
(7E)-7-[(4-methylphenyl)methylidene]-8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
-
 Photinus pyralis
2-benzylidene-1H-indene-1,3(2H)-dione
-
 Photinus pyralis
2-hydroxy-5-[(E)-(1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)methyl]benzoic acid
-
 Photinus pyralis
2-[(4-methylphenyl)methylidene]-1H-indene-1,3(2H)-dione
-
 Photinus pyralis
2-[(4-methylphenyl)methyl]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
2-[[4-(dimethylamino)phenyl]methyl]-3,4-dihydronaphthalen-1(2H)-one
-
 Photinus pyralis
3-(4-methylphenyl)-4,5-dihydro-2H-benzo[g]indazole
-
 Photinus pyralis
4-(4-methylphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
-
 Photinus pyralis
5-[(E)-(6-bromo-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)methyl]-2-hydroxybenzoic acid
-
 Photinus pyralis
additional information the extensive applications of Firefly luciferase in numerous biological, biomedical, and clinical investigations renders an urgent need for efficient and biocompatible Fluc inhibitors for the construction of novel assay platforms Photinus pyralis
resveratrol
-
 Photinus pyralis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-firefly luciferin + O2 + ATP Photinus pyralis
-
 firefly oxyluciferin + CO2 + AMP + diphosphate + hv
-
 ?

Organism

Organism UniProt Comment Textmining
Photinus pyralis P08659
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-firefly luciferin + O2 + ATP
-
 Photinus pyralis firefly oxyluciferin + CO2 + AMP + diphosphate + hv
-
 ?

Synonyms

Synonyms Comment Organism
fluc
-
 Photinus pyralis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000025
-
 pH and temperature not specified in the publication Photinus pyralis (6E)-6-[(3-carboxy-4-hydroxyphenyl)methylidene]-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
0.0000005
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0000005
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(dimethylamino)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0000012
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-ethylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0000012
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000007
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000007
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-ethoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000012
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(methylsulfanyl)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000031
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-fluorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000031
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-hydroxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000034
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(3-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000049
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(diethylamino)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000056
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00006
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(4-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000063
-
 pH and temperature not specified in the publication Photinus pyralis 2-[(4-methylphenyl)methylidene]-1H-indene-1,3(2H)-dione
0.00007
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
0.000088
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-benzylidene-3,4-dihydronaphthalen-1(2H)-one
0.00009
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(2-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000106
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-8-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00013
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(benzyloxy)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00014
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-5-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.000159
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-6-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00016
-
 pH and temperature not specified in the publication Photinus pyralis 2-benzylidene-1H-indene-1,3(2H)-dione
0.0002
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(2-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0002
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(dimethylamino)phenyl]methylidene]-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
0.00026
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(trifluoromethyl)phenyl]methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0004
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-1-(1-benzofuran-2-yl)-3-(4-methylphenyl)prop-2-en-1-one
0.00041
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-1-(5-chlorothiophen-2-yl)-3-phenylprop-2-en-1-one
0.00044
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(2-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00044
-
 pH and temperature not specified in the publication Photinus pyralis 5-[(E)-(6-bromo-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)methyl]-2-hydroxybenzoic acid
0.0005
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(2-methoxyphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.00056
-
 pH and temperature not specified in the publication Photinus pyralis 2-hydroxy-5-[(E)-(1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)methyl]benzoic acid
0.00058
-
 pH and temperature not specified in the publication Photinus pyralis 3-(4-methylphenyl)-4,5-dihydro-2H-benzo[g]indazole
0.0006
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(3-bromophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0011
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-1-(5-chlorothiophen-2-yl)-3-(4-methylphenyl)prop-2-en-1-one
0.0011
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(3-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0012
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(dimethylamino)phenyl]methylidene]-7-methoxy-3,4-dihydronaphthalen-1(2H)-one
0.0013
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(2-nitrophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0014
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(3-chlorophenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0015
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(3-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0018
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-1-(1-benzofuran-2-yl)-3-phenylprop-2-en-1-one
0.0018
-
 pH and temperature not specified in the publication Photinus pyralis 2-[[4-(dimethylamino)phenyl]methyl]-3,4-dihydronaphthalen-1(2H)-one
0.0019
-
 pH and temperature not specified in the publication Photinus pyralis resveratrol
0.002
-
 pH and temperature not specified in the publication Photinus pyralis (7E)-7-[(4-methylphenyl)methylidene]-8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
0.0024
-
 pH and temperature not specified in the publication Photinus pyralis 2-[(4-methylphenyl)methyl]-3,4-dihydronaphthalen-1(2H)-one
0.00286
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-7-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
0.0059
-
 pH and temperature not specified in the publication Photinus pyralis 4-(4-methylphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
0.007
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[[4-(dimethylamino)phenyl]methylidene]-8-methoxy-3,4-dihydronaphthalen-1(2H)-one
0.0109
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-2-[(pyridin-3-yl)methylidene]-3,4-dihydronaphthalen-1(2H)-one
122
-
 pH and temperature not specified in the publication Photinus pyralis (2E)-7-methoxy-2-[(4-methylphenyl)methylidene]-3,4-dihydronaphthalen-1(2H)-one