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Literature summary for 1.13.12.7 extracted from

  • Auld, D.S.; Southall, N.T.; Jadhav, A.; Johnson, R.L.; Diller, D.J.; Simeonov, A.; Austin, C.P.; Inglese, J.
    Characterization of chemical libraries for luciferase inhibitory activity (2008), J. Med. Chem., 51, 2372-2386.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid common name indoprofen Photinus pyralis
(2Z)-1-(4-chlorophenyl)-3-(pyridin-2-ylamino)prop-2-en-1-one
-
Photinus pyralis
(2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one
-
Photinus pyralis
(2Z)-3-[(4-fluorophenyl)amino]-1-furan-2-ylprop-2-en-1-one
-
Photinus pyralis
(2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one
-
Photinus pyralis
(3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one common name SU4312 Photinus pyralis
1-[3-(6-ethoxy-1,3-benzothiazol-2-yl)thiophen-2-yl]urea
-
Photinus pyralis
2,4-dimethoxy-N-(5-methylpyridin-2-yl)benzamide
-
Photinus pyralis
2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one common name PD98059 Photinus pyralis
2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone common name pifithrin-alpha Photinus pyralis
2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline
-
Photinus pyralis
2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline
-
Photinus pyralis
2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline
-
Photinus pyralis
2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine
-
Photinus pyralis
2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine
-
Photinus pyralis
2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide common name SCS Photinus pyralis
2-methyl-6-(phenylethynyl)pyridine common name MPEB Photinus pyralis
2-methyl-6-[(Z)-2-phenylethenyl]pyridine common name SIB1893 Photinus pyralis
2-[5-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
-
Photinus pyralis
2-[5-(3-chloro-4-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridine
-
Photinus pyralis
2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
-
Photinus pyralis
2-[5-(5-bromofuran-2-yl)-1,2,4-oxadiazol-3-yl]pyridine
-
Photinus pyralis
3-(2-hydroxyphenyl)-1H-benzo[f]chromen-1-one common name flavonoid Photinus pyralis
4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline
-
Photinus pyralis
4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate common name Evans Blue Photinus pyralis
4-methoxy-N-[(4-methylpyridin-2-yl)carbamoyl]benzamide
-
Photinus pyralis
4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol
-
Photinus pyralis
5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole
-
Photinus pyralis
5-(2-bromophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
-
Photinus pyralis
5-(2-chloro-4-methylphenyl)-3-phenyl-1,2,4-oxadiazole
-
Photinus pyralis
5-methyl-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide
-
Photinus pyralis
5-naphthalen-2-yl-3-phenyl-1,2,4-oxadiazole
-
Photinus pyralis
6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol common name SIB1757 Photinus pyralis
ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate
-
Photinus pyralis
N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide common name DCB Photinus pyralis
N-(4-ethoxyphenyl)-2-methoxybenzamide
-
Photinus pyralis
N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide
-
Photinus pyralis
N-(6-methoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide
-
Photinus pyralis
N-(6-methyl-1,3-benzothiazol-2-yl)thiophene-2-carboxamide
-
Photinus pyralis
N-[5-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl]-3-hydroxybenzamide
-
Photinus pyralis
N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide
-
Photinus pyralis

Organism

Organism UniProt Comment Textmining
Photinus pyralis Q27758
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-luciferin + O2 + ATP
-
Photinus pyralis oxidized D-luciferin + CO2 + H2O + AMP + diphosphate + hv
-
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Synonyms

Synonyms Comment Organism
firefly luciferase
-
Photinus pyralis
Luc
-
Photinus pyralis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
-
Photinus pyralis 3-(2-hydroxyphenyl)-1H-benzo[f]chromen-1-one
0.00008
-
-
Photinus pyralis (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one
0.00008
-
-
Photinus pyralis 2,4-dimethoxy-N-(5-methylpyridin-2-yl)benzamide
0.0001
-
-
Photinus pyralis 2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0001
-
-
Photinus pyralis 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine
0.00015
-
-
Photinus pyralis 5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole
0.00015
-
-
Photinus pyralis 5-(2-chloro-4-methylphenyl)-3-phenyl-1,2,4-oxadiazole
0.0002
-
-
Photinus pyralis (2R)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
0.00021
-
-
Photinus pyralis (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one
0.00022
-
-
Photinus pyralis 2-[5-(3-chloro-4-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridine
0.0003
-
-
Photinus pyralis 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol
0.00032
-
-
Photinus pyralis 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone
0.00041
-
-
Photinus pyralis 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline
0.00041
-
-
Photinus pyralis 4-methoxy-N-[(4-methylpyridin-2-yl)carbamoyl]benzamide
0.00041
-
-
Photinus pyralis 5-naphthalen-2-yl-3-phenyl-1,2,4-oxadiazole
0.0005
-
-
Photinus pyralis 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
0.0005
-
-
Photinus pyralis N-(6-methyl-1,3-benzothiazol-2-yl)thiophene-2-carboxamide
0.0006
-
-
Photinus pyralis 1-[3-(6-ethoxy-1,3-benzothiazol-2-yl)thiophen-2-yl]urea
0.0006
-
-
Photinus pyralis N-(4-ethoxyphenyl)-2-methoxybenzamide
0.00065
-
-
Photinus pyralis N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide
0.0007
-
-
Photinus pyralis 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline
0.0007
-
-
Photinus pyralis N-[5-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl]-3-hydroxybenzamide
0.0008
-
-
Photinus pyralis (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one
0.0008
-
-
Photinus pyralis 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide
0.00084
-
-
Photinus pyralis 2-[5-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
0.0009
-
-
Photinus pyralis ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate
0.001
-
-
Photinus pyralis (2Z)-3-[(4-fluorophenyl)amino]-1-furan-2-ylprop-2-en-1-one
0.001
-
-
Photinus pyralis 5-(2-bromophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
0.0011
-
-
Photinus pyralis 5-methyl-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide
0.0011
-
-
Photinus pyralis N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide
0.0012
-
-
Photinus pyralis N-(6-methoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide
0.0013
-
-
Photinus pyralis 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline
0.0017
-
-
Photinus pyralis 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate
0.002
-
-
Photinus pyralis (2Z)-1-(4-chlorophenyl)-3-(pyridin-2-ylamino)prop-2-en-1-one
0.0032
-
-
Photinus pyralis 2-[5-(5-bromofuran-2-yl)-1,2,4-oxadiazol-3-yl]pyridine
0.004
-
-
Photinus pyralis 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline
0.0043
-
-
Photinus pyralis 2-methyl-6-[(Z)-2-phenylethenyl]pyridine
0.0045
-
-
Photinus pyralis 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol
0.0045
-
-
Photinus pyralis N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide
0.0047
-
-
Photinus pyralis 2-methyl-6-(phenylethynyl)pyridine
0.0062
-
-
Photinus pyralis 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one