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Literature summary for 1.13.12.5 extracted from

  • Badr, C.; Hewett, J.; Breakefield, X.; Tannous, B.
    A highly sensitive assay for monitoring the secretory pathway and ER stress (2007), PLoS ONE, 6, e571.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information Gluc reporter as a sensitive marker in elucidation endoplasmic reticulum stress in mammalian cells Gaussia princeps
additional information monitor processing of proteins through the secretory pathway and endoplasmic reticulum Gaussia princeps

Cloned(Commentary)

Cloned (Comment) Organism
expression in 293T HEK fibroblasts and HF8 human fibroblasts Gaussia princeps

Protein Variants

Protein Variants Comment Organism
additional information fusion of Gluc to fluorescent protein YFP Gaussia princeps

Inhibitors

Inhibitors Comment Organism Structure
brefeldinA 5 microg/ml, 24 h, 90% decrease of Gluc secretion Gaussia princeps
cytochalasin B 5 microg7ml, 24 h, 30% decrease of Gluc secretion Gaussia princeps
dithiothreitol 1 mM, complete inhibition of secretion for the first 3 h, secretion returned to normal level after 24 h Gaussia princeps
monensin A 3 microg/ml, 24 h, 65% decrease of Gluc secretion Gaussia princeps
nocodazole 10 microg/ml, 24 h, 75% decrease of Gluc secretion Gaussia princeps
thapsigargin 0.03 microM, about 30% decrease of Gluc secretion and activity Gaussia princeps
tunicamycin
-
Gaussia princeps

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Gaussia princeps 5783
-
additional information secreted Gaussia princeps
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
Western blot, fusion protein Gluc-YFP Gaussia princeps

Organism

Organism UniProt Comment Textmining
Gaussia princeps
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beetle D-luciferin 450 microM Gaussia princeps ?
-
?
coelenterazine + ? 20 microM Gaussia princeps ?
-
?

Synonyms

Synonyms Comment Organism
firefly luciferase
-
Gaussia princeps
fluc
-
Gaussia princeps
Gaussia luciferase
-
Gaussia princeps