BRENDA - Enzyme Database show
show all sequences of 1.13.12.5

Development of a high-throughput human hepG2 dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants

Liu, X.; Kramer, J.A.; Hu, Y.; Schmidt, J.M.; Jiang, J.; Wilson, A.G.E.; Int. J. Toxicol. 28, 162-179 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
pharmacology
used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage
Renilla sp.
Cloned(Commentary)
Commentary
Organism
expression in Hep-G2 cell
Renilla sp.
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-acetylaminofluorene
-
Renilla sp.
2-aminoanthracene
-
Renilla sp.
2-nitrofluorene
-
Renilla sp.
4-acetylaminofluorene
-
Renilla sp.
4-nitroquinoline-N-oxide
-
Renilla sp.
acetaminophen
-
Renilla sp.
actinomycin D
-
Renilla sp.
albendazole
-
Renilla sp.
amiodarone
-
Renilla sp.
ara C
-
Renilla sp.
arsenic III oxide
-
Renilla sp.
bleomycin
-
Renilla sp.
carbamzepine
-
Renilla sp.
chlorambucil
-
Renilla sp.
chlorpromazine
-
Renilla sp.
cisplatin
-
Renilla sp.
cyclophosphamide
-
Renilla sp.
cyclosporin A
-
Renilla sp.
cytochalasin B
-
Renilla sp.
digoxin
-
Renilla sp.
dimethylnitrosamine
-
Renilla sp.
ethyl methanesulfonate
-
Renilla sp.
etoposide
-
Renilla sp.
gemfibrozil
-
Renilla sp.
haloperidol
-
Renilla sp.
methylmethane sulfonate
-
Renilla sp.
mitomycin
-
Renilla sp.
N-methyl-N'-nitro-nitroso-guanidin
-
Renilla sp.
nefazodone
-
Renilla sp.
phenytoin
-
Renilla sp.
Sodium azide
-
Renilla sp.
tacrine
-
Renilla sp.
taxol
-
Renilla sp.
troglitazone
-
Renilla sp.
Valproic acid
-
Renilla sp.
vinblastin
-
Renilla sp.
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Renilla sp.
-
-
-
Application (protein specific)
Application
Commentary
Organism
pharmacology
used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage
Renilla sp.
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Hep-G2 cell
Renilla sp.
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-acetylaminofluorene
-
Renilla sp.
2-aminoanthracene
-
Renilla sp.
2-nitrofluorene
-
Renilla sp.
4-acetylaminofluorene
-
Renilla sp.
4-nitroquinoline-N-oxide
-
Renilla sp.
acetaminophen
-
Renilla sp.
actinomycin D
-
Renilla sp.
albendazole
-
Renilla sp.
amiodarone
-
Renilla sp.
ara C
-
Renilla sp.
arsenic III oxide
-
Renilla sp.
bleomycin
-
Renilla sp.
carbamzepine
-
Renilla sp.
chlorambucil
-
Renilla sp.
chlorpromazine
-
Renilla sp.
cisplatin
-
Renilla sp.
cyclophosphamide
-
Renilla sp.
cyclosporin A
-
Renilla sp.
cytochalasin B
-
Renilla sp.
digoxin
-
Renilla sp.
dimethylnitrosamine
-
Renilla sp.
ethyl methanesulfonate
-
Renilla sp.
etoposide
-
Renilla sp.
gemfibrozil
-
Renilla sp.
haloperidol
-
Renilla sp.
methylmethane sulfonate
-
Renilla sp.
mitomycin
-
Renilla sp.
N-methyl-N'-nitro-nitroso-guanidin
-
Renilla sp.
nefazodone
-
Renilla sp.
phenytoin
-
Renilla sp.
Sodium azide
-
Renilla sp.
tacrine
-
Renilla sp.
taxol
-
Renilla sp.
troglitazone
-
Renilla sp.
Valproic acid
-
Renilla sp.
vinblastin
-
Renilla sp.
Other publictions for EC 1.13.12.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745436
Kahrani
New Insights into the Molecul ...
Renilla reniformis
J. Cell. Biochem.
119
1780-1790
2018
-
1
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1
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1
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2
1
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1
1
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744428
Fanaei Kahrani
Molecular basis of thermostab ...
Renilla reniformis
Biochim. Biophys. Acta
1865
252-259
2017
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1
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1
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2
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1
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3
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1
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1
1
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1
1
1
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3
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1
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1
1
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744813
Rahnama
Super RLuc8 A novel engineere ...
Renilla reniformis
Enzyme Microb. Technol.
96
60-66
2017
-
1
1
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2
-
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2
-
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1
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2
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1
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1
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2
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1
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1
1
2
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2
-
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1
1
-
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-
745101
Liyaghatdar
Trehalose radial networks pro ...
Renilla reniformis
Int. J. Biol. Macromol.
105
66-73
2017
-
1
1
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1
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1
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3
-
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1
1
2
2
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1
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1
1
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1
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1
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-
1
1
2
2
-
1
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-
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745694
Farkas
Renilla luciferase-LC3 based ...
Renilla reniformis
Methods Enzymol.
588
1-13
2017
-
1
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1
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1
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1
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1
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1
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-
746365
Shigehisa
Stabilization of luciferase f ...
Renilla reniformis
Protein Eng. Des. Sel.
30
7-13
2017
-
-
1
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8
-
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-
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1
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1
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1
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2
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1
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3
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1
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1
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8
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1
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1
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-
-
2
-
1
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3
-
1
-
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-
1
1
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-
-
743975
Wang
The split Renilla luciferase ...
Renilla reniformis
Acta Virol.
60
62-70
2016
-
1
-
-
-
-
-
-
-
-
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3
-
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1
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744253
Ghaedizadeh
-
Understanding the molecular b ...
Renilla reniformis
Biochem. Eng. J.
105
505-513
2016
-
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1
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4
-
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1
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1
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1
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-
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1
1
1
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1
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1
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4
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1
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1
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-
1
1
1
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1
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1
1
-
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-
745096
Salehi
Probing the emitter site of R ...
Renilla reniformis
Int. J. Biol. Macromol.
93
1253-1260
2016
-
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1
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3
2
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1
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2
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1
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3
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1
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1
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2
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1
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3
2
2
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1
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1
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-
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3
-
1
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-
-
1
-
-
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-
1
1
-
-
-
745957
Jiang
Novel bioluminescent coelente ...
Renilla reniformis
Org. Biomol. Chem.
14
5272-5281
2016
-
-
1
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-
1
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1
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2
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11
-
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1
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1
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1
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1
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11
-
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1
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-
744017
Farzannia
FcUni-RLuc an engineered Reni ...
Renilla reniformis
Analyst
140
1438-1441
2015
-
3
1
-
-
-
-
3
-
-
-
1
-
2
-
-
1
-
-
-
-
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2
1
1
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1
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3
1
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3
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1
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1
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2
1
1
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-
1
-
-
-
-
-
-
-
-
-
728741
Inouye
Expression, purification and l ...
Gaussia, Oplophorus gracilirostris, Renilla reniformis
Protein Expr. Purif.
88
150-156
2013
-
-
3
-
-
-
-
-
-
-
4
-
-
7
-
-
3
-
-
-
-
-
43
-
-
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-
-
3
-
-
-
-
-
-
-
-
3
-
-
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4
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3
-
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43
-
-
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-
-
3
-
-
-
-
-
-
-
-
-
728746
Song
Novel functional Renilla lucif ...
Renilla reniformis
Protein Expr. Purif.
91
215-220
2013
-
-
1
-
1
-
-
-
-
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1
-
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3
-
-
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-
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1
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1
-
1
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1
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1
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1
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1
-
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1
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
728582
Hatzios
Studies of dynamic protein-pro ...
Renilla reniformis
PLoS ONE
7
e43175
2012
-
1
1
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-
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4
-
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1
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1
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1
1
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1
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1
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710838
Stepanyuk
Coelenterazine-v ligated to Ca ...
Renilla muelleri
Anal. Bioanal. Chem.
398
1809-1817
2010
-
-
-
-
1
-
-
-
-
-
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3
-
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-
-
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3
-
1
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1
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1
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-
3
-
1
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-
-
1
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-
-
1
1
-
-
-
710900
Liu
Measuring antiviral activity o ...
Renilla reniformis
Antiviral Res.
89
54-63
2010
-
-
-
-
1
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-
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-
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-
4
-
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1
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-
712443
Jiang
Split Renilla luciferase prote ...
Renilla reniformis
J. Biol. Chem.
285
21023-21036
2010
-
1
-
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1
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-
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3
-
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-
712977
Huang
A quantitative assay for mitoc ...
Renilla reniformis
Mitochondrion
10
559-566
2010
-
1
1
-
1
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-
-
1
-
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2
-
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1
1
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1
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1
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-
695537
Andou
RNA detection using peptide-in ...
Renilla sp.
Anal. Bioanal. Chem.
393
661-668
2009
-
-
1
-
12
-
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-
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4
-
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1
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2
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1
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12
-
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1
-
2
-
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-
-
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-
-
-
-
-
695563
Maguire
Gaussia luciferase variant for ...
Gaussia princeps (T. Scott, 1894)
Anal. Chem.
81
7102-7106
2009
2
1
1
-
2
-
-
-
1
-
1
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2
-
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1
-
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1
-
1
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1
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2
1
1
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-
2
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1
-
1
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1
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1
-
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
696059
Patel
Cell-free production of Gaussi ...
Gaussia princeps (T. Scott, 1894)
Biochem. Biophys. Res. Commun.
390
971-976
2009
-
1
1
-
2
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
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1
1
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2
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1
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
696498
Cissell
Reassembly of a bioluminescent ...
Renilla sp.
Bioconjug. Chem.
20
15-19
2009
2
-
1
-
3
-
1
-
-
-
2
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
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-
-
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-
-
-
2
-
1
-
-
3
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698372
Liu
Development of a high-throughp ...
Renilla sp.
Int. J. Toxicol.
28
162-179
2009
-
1
1
-
-
-
36
-
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Hanson
Hormone treatment enhances WT1 ...
Renilla reniformis
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Hoshino
Luciferase-YFP fusion tag with ...
Renilla reniformis
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700910
Badr
A highly sensitive assay for m ...
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Inouye
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676876
Tricoire
Calcium dependence of aequorin ...
Aequorea victoria
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676939
Loening
Consensus guided mutagenesis o ...
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Bifunctional antibody-Renilla ...
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Deng
All three Ca2+-binding loops o ...
Aequorea victoria
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656302
Bhaumik
Optical imaging of Renilla luc ...
Renilla reniformis
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656822
Zhao
Characterization of coelentera ...
Renilla reniformis
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657215
Mulholland
Androgen responsiveness of Ren ...
Renilla reniformis
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673608
Inouye
Blue fluorescent protein from ...
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Recombinant Gaussia luciferase ...
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671287
Dyer
A noncommercial dual luciferas ...
Renilla reniformis
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439339
Liu
Improved assay sensitivity of ...
Renilla reniformis
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Liu
Secretion of functional Renill ...
Renilla reniformis
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673606
Inouye
Cloning and sequence analysis ...
Clytia gregaria
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Hart
Renilla reniformis bioluminesc ...
Renilla reniformis
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1979
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439334
Matthews
Purification and properties of ...
Renilla reniformis
Biochemistry
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85-91
1977
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439337
Matthews
Substrate and substrate analog ...
Renilla reniformis
Biochemistry
16
5217-5220
1977
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439333
Cormier
Bioluminescence in coelenterat ...
Renilla koellikeri, Renilla muelleri, Renilla reniformis
Biochim. Biophys. Acta
346
137-164
1974
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439335
DeLuca
Mechanism of oxidative carbon ...
Renilla reniformis
Proc. Natl. Acad. Sci. USA
68
1658-1660
1971
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439338
Karkhanis
Isolation and properties of Re ...
Renilla reniformis
Biochemistry
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317-326
1971
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