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Literature summary for 1.13.12.3 extracted from

  • Sobrado, P.; Fitzpatrick, P.F.
    Analysis of the role of the active site residue Arg98 in the flavoprotein tryptophan 2-monooxygenase, a member of the L-amino oxidase family (2003), Biochemistry, 42, 13826-13832.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
R98A decrease in Vmax, increase in Km-value of tryptophan Pseudomonas savastanoi
R98K decrease in Vmax, increase in Km-value of tryptophan Pseudomonas savastanoi

Inhibitors

Inhibitors Comment Organism Structure
3-Indoleacetamide
-
Pseudomonas savastanoi
3-indolepyruvate
-
Pseudomonas savastanoi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
tryptophan pH 8.3, 25°C, wild-type Pseudomonas savastanoi
0.067
-
O2 pH 8.3, 25°C, mutant R98A Pseudomonas savastanoi
0.09
-
O2 pH 8.3, 25°C, wild-type Pseudomonas savastanoi
0.14
-
O2 pH 8.3, 25°C, mutant R98K Pseudomonas savastanoi
3.3
-
tryptophan pH 8.3, 25°C, mutant R98A Pseudomonas savastanoi
30
-
tryptophan pH 8.3, 25°C, mutant R98K Pseudomonas savastanoi

Organism

Organism UniProt Comment Textmining
Pseudomonas savastanoi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
Pseudomonas savastanoi indole-3-acetamide + CO2 + H2O
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.21
-
tryptophan pH 8.3, 25°C, mutant R98A Pseudomonas savastanoi
1.05
-
tryptophan pH 8.3, 25°C, mutant R98K Pseudomonas savastanoi
13.2
-
tryptophan pH 8.3, 25°C, wild-type Pseudomonas savastanoi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
16
-
3-Indoleacetamide pH 8.3, 25°C, wild-type Pseudomonas savastanoi
20
-
3-Indoleacetamide pH 8.3, 25°C, mutant R98K Pseudomonas savastanoi
40
-
3-indolepyruvate pH 8.3, 25°C, wild-type Pseudomonas savastanoi
45
-
3-Indoleacetamide pH 8.3, 25°C, mutant R98A Pseudomonas savastanoi
471
-
3-indolepyruvate pH 8.3, 25°C, mutant R98K Pseudomonas savastanoi
670
-
3-indolepyruvate pH 8.3, 25°C, mutant R98A Pseudomonas savastanoi