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Literature summary for 1.13.12.2 extracted from

  • Ohnishi, T.; Yamamoto, S.; Hayaishi, O.; Izumi, T.; Shiba, T.
    Studies on the reaction specificity of the flavoprotein lysine monooxygenase with modified substrates (1976), Arch. Biochem. Biophys., 176, 358-365.
    View publication on PubMed
Search for more literature for 1.13.12.2

Activating Compound

Activating Compound Comment Organism Structure
4-Methyllysine at low substrate concentrations Pseudomonas fluorescens
5-Methyllysine at low substrate concentrations Pseudomonas fluorescens
Nepsilon-Methyllysine at low substrate concentrations Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
4-Methyllysine at higher substrate concentrations, competitive inhibitor Pseudomonas fluorescens
5-Methyllysine at higher substrate concentrations, competitive inhibitor Pseudomonas fluorescens
Nepsilon-Methyllysine at higher substrate concentrations, competitive inhibitor Pseudomonas fluorescens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Pseudomonas fluorescens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metals play no role in lysine monooxygenase Pseudomonas fluorescens

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-chlorolysine + O2 oxidase activity Pseudomonas fluorescens ?
-
 ?
4-methyllysine + O2 oxidase activity Pseudomonas fluorescens 2-keto-4-methyl-6-amino-n-hexanoate + NH3 + H2O2
-
 ?
5-hydroxylysine + O2 oxidase activity Pseudomonas fluorescens ?
-
 ?
5-methyllysine + O2 monooxygenase activity Pseudomonas fluorescens 4-methyl-5-aminopentanamide + CO2 + H2O
-
 ?
L-homoarginine + O2
-
 Pseudomonas fluorescens ?
-
 ?
L-lysine + O2 monooxygenase activity Pseudomonas fluorescens 5-aminopentanamide + CO2 + H2O
-
 ?
additional information analogs with a modified carboxyl or alpha-amino group are inactive as substrates Pseudomonas fluorescens ?
-
 ?
additional information L-lysine analogs with a chloro or hydroxyl group at either the delta or the gamma position are both oxygenated and oxidized Pseudomonas fluorescens ?
-
 ?
Nepsilon-methyllysine + O2 monooxygenase activity Pseudomonas fluorescens 5-methylaminopentanamide + CO2 + H2O
-
 ?
threo-4-hydroxy-L-lysine + O2 oxidase activity Pseudomonas fluorescens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
34
-
 assay at Pseudomonas fluorescens

Cofactor

Cofactor Comment Organism Structure
FAD contains 2 mol of FAD per mol of enzyme Pseudomonas fluorescens