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Literature summary for 1.13.11.84 extracted from

  • Frusciante, S.; Diretto, G.; Bruno, M.; Ferrante, P.; Pietrella, M.; Prado-Cabrero, A.; Rubio-Moraga, A.; Beyer, P.; Gomez-Gomez, L.; Al-Babili, S.; Giuliano, G.
    Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis (2014), Proc. Natl. Acad. Sci. USA, 111, 12246-12251 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and in Zea mays endosperm Crocus sativus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3beta-hydroxy-8'-apo-beta-carotenal + O2 Crocus sativus
-
 crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral
-
 ?
additional information Crocus sativus the enzyme cleaves sequentially the 7,8 and 7',8' double bonds adjacent to a 3-OH-beta-ionone ring. The conversion of zeaxanthin to crocetin dialdehyde proceeds via the C30 intermediate 3-OH-beta-apo-8'-carotenal ?
-
 ?
zeaxanthin + O2 Crocus sativus
-
 3beta-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
-
 ?
zeaxanthin + O2 Crocus sativus overall reaction crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral
-
 ?

Organism

Organism UniProt Comment Textmining
Crocus sativus A0A075W695
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Crocus sativus
-
stigma
-
 Crocus sativus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta-hydroxy-8'-apo-beta-carotenal + O2
-
 Crocus sativus crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral
-
 ?
additional information the enzyme cleaves sequentially the 7,8 and 7',8' double bonds adjacent to a 3-OH-beta-ionone ring. The conversion of zeaxanthin to crocetin dialdehyde proceeds via the C30 intermediate 3-OH-beta-apo-8'-carotenal Crocus sativus ?
-
 ?
zeaxanthin + O2
-
 Crocus sativus 3beta-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral
-
 ?
zeaxanthin + O2 overall reaction Crocus sativus crocetin dialdehyde + 3beta-hydroxy-beta-cyclocitral
-
 ?

Synonyms

Synonyms Comment Organism
carotenoid cleavage dioxygenase 2
-
 Crocus sativus
CCD2
-
 Crocus sativus