Literature summary for 1.13.11.71 extracted from

Wu, L.; Guo, X.; Hartson, S.D.; Davis, M.A.; He, H.; Medeiros, D.M.; Wang, W.; Clarke, S.L.; Lucas, E.A.; Smith, B.J.; von Lintig, J.; Lin, D.
Lack of beta, beta-carotene-9',10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice (2017), Mol. Nutr. Food Res., 61, 10 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
inner mitochondrial membrane	-	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
all-trans-beta-carotene + O2	Mus musculus	-	all-trans-10'-apo-beta-carotenal + beta-ionone	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99NF1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
all-trans-beta-carotene + O2	-	Mus musculus	all-trans-10'-apo-beta-carotenal + beta-ionone	-	?

Synonyms

Synonyms	Comment	Organism
BCO2	-	Mus musculus
beta,beta-carotene-9',10'-dioxygenase 2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	enzyme loss induces mitochondrial hyperactivation, mitochondrial stress and changes of the mitochondrial proteome, leading to mitochondrial energy insufficiency	Mus musculus
physiological function	the enzyme is critical for proper hepatic mitochondrial function	Mus musculus

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Release 2023.1 (January 2023)