Literature summary for 1.13.11.71 extracted from

Guo, X.; Wu, L.; Lyu, Y.; Chowanadisai, W.; Clarke, S.L.; Lucas, E.A.; Smith, B.J.; He, H.; Wang, W.; Medeiros, D.M.; Lin, D.
Ablation of beta,beta-carotene-9,10-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice (2017), J. Nutr. Biochem., 46, 74-82 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial inner membrane	-	Mus musculus	5743	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
all-trans-beta-carotene + O2	Mus musculus	-	all-trans-10'-apo-beta-carotenal + beta-ionone	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99NF1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
hypothalamus	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
all-trans-beta-carotene + O2	-	Mus musculus	all-trans-10'-apo-beta-carotenal + beta-ionone	-	?

Synonyms

Synonyms	Comment	Organism
BCO2	-	Mus musculus
beta,beta-carotene-9,10-oxygenase 2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	systemic depletion of BCO2 causes increased food intake and impaired hepatic lipid metabolism in mice. Compared to wild-type, BCO2 knockout mice exhibit widespread disruptions in metabolism and metabolite homeostasis, an increase in fasting blood glucose, a decrease in circulating glucagon and leptin, an elevation of plasma interleukin 1 beta and tumor necrosis factor alpha, and impaired AMP activated protein kinase signaling. The global hypothalamic metabolomic results reveal that depletion of BCO2 results in striking metabolic changes, including suppression of long-chain fatty acids transport into mitochondria, inhibition of the metabolism of dipeptides and sulfur-containing amino acids, and stimulation of local oxidative stress and inflammation in the hypothalamus of BCO2 knockout mice. Complex interplay between the hormone signaling and impaired lipid and glucose metabolism seems to account for initiation of oxidative stress, inflammation and eventual metabolic disorders in BCO2 knockout mice. Phenotype, overview	Mus musculus
physiological function	the enzyme catalyzes the asymmetric cleavage of carotenoids. Enzyme BCO2 exerts its role in hypothalamic nutrient metabolism and feeding behavior. BCO2 regulates hypothalamic mitochondrial function, nutrient metabolism, and local oxidative stress and inflammation	Mus musculus

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Release 2023.1 (January 2023)