BRENDA - Enzyme Database show
show all sequences of 1.13.11.71

Purification and characterization of a novel beta-carotene-9',10'-oxygenase from Saccharomyces cerevisiae ULI3

Wei, T.; Jia, B.; Huang, S.; Yang, K.; Jia, C.; Mao, D.; Biotechnol. Lett. 37, 1993-1998 (2015)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
DTT
activates by 27% at 5 mM
Saccharomyces cerevisiae
Triton X-100
activates by 7% at 1% w/v
Saccharomyces cerevisiae
Tween 20
activates by 3% at 1% w/v
Saccharomyces cerevisiae
Application
Application
Commentary
Organism
synthesis
enzyme ScBCO2 potentially can be used for the enzymatic biotransformation of beta-carotene to beta-apo-10'-carotenal in biotechnological applications
Saccharomyces cerevisiae
Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
inhibits by 10% at 5 mM
Saccharomyces cerevisiae
Fe2+
inhibits by 37% at 5 mM
Saccharomyces cerevisiae
Mn2+
inhibits by 13% at 5 mM
Saccharomyces cerevisiae
SDS
99% inhibition at 1 %
Saccharomyces cerevisiae
Urea
86% inhibition at 4 M
Saccharomyces cerevisiae
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.037
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.048
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.105
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates by 26% at 5 mM
Saccharomyces cerevisiae
Cu2+
activates by 23% at 5 mM
Saccharomyces cerevisiae
Mg2+
activates by 14% at 5 mM
Saccharomyces cerevisiae
Ni2+
activates by 7% at 5 mM
Saccharomyces cerevisiae
Zn2+
activates by 17% at 5 mM
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-beta-carotene + O2
Saccharomyces cerevisiae
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
all-trans-beta-carotene + O2
Saccharomyces cerevisiae ULI3
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
alpha-carotene + O2
Saccharomyces cerevisiae
-
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
?
alpha-carotene + O2
Saccharomyces cerevisiae ULI3
-
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
?
lutein + O2
Saccharomyces cerevisiae
-
?
-
-
?
lutein + O2
Saccharomyces cerevisiae ULI3
-
?
-
-
?
additional information
Saccharomyces cerevisiae
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
?
-
-
-
additional information
Saccharomyces cerevisiae ULI3
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
?
-
-
-
Organic Solvent Stability
Organic Solvent
Commentary
Organism
2-butanone
inhibits 66% at 50 v/v
Saccharomyces cerevisiae
Acetone
inhibits 20% at 50 v/v
Saccharomyces cerevisiae
benzene
inhibits 28% at 50 v/v
Saccharomyces cerevisiae
chloroform
inhibits 57% at 50 v/v
Saccharomyces cerevisiae
dichloromethane
inhibits 49% at 50 v/v
Saccharomyces cerevisiae
dimethylformamide
inhibits 24% at 50 v/v
Saccharomyces cerevisiae
DMSO
inhibits 17% at 50 v/v
Saccharomyces cerevisiae
toluene
inhibits 28% at 50 v/v
Saccharomyces cerevisiae
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae ULI3
-
-
-
Purification (Commentary)
Commentary
Organism
native enzyme 9.5fold to homogeneity by ammonium sulfate fractionation and gel filtration
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.38
-
purified native enzyme, pH 8.0, 45°C
Saccharomyces cerevisiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-beta-carotene + O2
-
744574
Saccharomyces cerevisiae
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
all-trans-beta-carotene + O2
-
744574
Saccharomyces cerevisiae ULI3
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
alpha-carotene + O2
-
744574
Saccharomyces cerevisiae
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
-
?
alpha-carotene + O2
-
744574
Saccharomyces cerevisiae ULI3
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
-
?
lutein + O2
-
744574
Saccharomyces cerevisiae
?
-
-
-
?
lutein + O2
-
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
?
additional information
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
744574
Saccharomyces cerevisiae
?
-
-
-
-
additional information
enzyme ScBCO2 only exhibits cleavage activity towards carotenoid substrates containing two beta-ionone rings and its catalytic efficiency (kcat/Km) follows the descending order beta-carotene, alpha-carotene, lutein
744574
Saccharomyces cerevisiae
?
-
-
-
-
additional information
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
-
additional information
enzyme ScBCO2 only exhibits cleavage activity towards carotenoid substrates containing two beta-ionone rings and its catalytic efficiency (kcat/Km) follows the descending order beta-carotene, alpha-carotene, lutein
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Saccharomyces cerevisiae
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Saccharomyces cerevisiae
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
25
65
activity range, profile overview
Saccharomyces cerevisiae
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0167
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
0.0392
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.0475
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Saccharomyces cerevisiae
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7
9
50 % of the maximal activity at pH 7.0 and pH 9.0, 20% at pH 6.0 and pH 9.5
Saccharomyces cerevisiae
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
DTT
activates by 27% at 5 mM
Saccharomyces cerevisiae
Triton X-100
activates by 7% at 1% w/v
Saccharomyces cerevisiae
Tween 20
activates by 3% at 1% w/v
Saccharomyces cerevisiae
Application (protein specific)
Application
Commentary
Organism
synthesis
enzyme ScBCO2 potentially can be used for the enzymatic biotransformation of beta-carotene to beta-apo-10'-carotenal in biotechnological applications
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
inhibits by 10% at 5 mM
Saccharomyces cerevisiae
Fe2+
inhibits by 37% at 5 mM
Saccharomyces cerevisiae
Mn2+
inhibits by 13% at 5 mM
Saccharomyces cerevisiae
SDS
99% inhibition at 1 %
Saccharomyces cerevisiae
Urea
86% inhibition at 4 M
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.037
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.048
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.105
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates by 26% at 5 mM
Saccharomyces cerevisiae
Cu2+
activates by 23% at 5 mM
Saccharomyces cerevisiae
Mg2+
activates by 14% at 5 mM
Saccharomyces cerevisiae
Ni2+
activates by 7% at 5 mM
Saccharomyces cerevisiae
Zn2+
activates by 17% at 5 mM
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-beta-carotene + O2
Saccharomyces cerevisiae
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
all-trans-beta-carotene + O2
Saccharomyces cerevisiae ULI3
-
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
?
alpha-carotene + O2
Saccharomyces cerevisiae
-
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
?
alpha-carotene + O2
Saccharomyces cerevisiae ULI3
-
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
?
lutein + O2
Saccharomyces cerevisiae
-
?
-
-
?
lutein + O2
Saccharomyces cerevisiae ULI3
-
?
-
-
?
additional information
Saccharomyces cerevisiae
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
?
-
-
-
additional information
Saccharomyces cerevisiae ULI3
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
?
-
-
-
Organic Solvent Stability (protein specific)
Organic Solvent
Commentary
Organism
2-butanone
inhibits 66% at 50 v/v
Saccharomyces cerevisiae
Acetone
inhibits 20% at 50 v/v
Saccharomyces cerevisiae
benzene
inhibits 28% at 50 v/v
Saccharomyces cerevisiae
chloroform
inhibits 57% at 50 v/v
Saccharomyces cerevisiae
dichloromethane
inhibits 49% at 50 v/v
Saccharomyces cerevisiae
dimethylformamide
inhibits 24% at 50 v/v
Saccharomyces cerevisiae
DMSO
inhibits 17% at 50 v/v
Saccharomyces cerevisiae
toluene
inhibits 28% at 50 v/v
Saccharomyces cerevisiae
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme 9.5fold to homogeneity by ammonium sulfate fractionation and gel filtration
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.38
-
purified native enzyme, pH 8.0, 45°C
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-beta-carotene + O2
-
744574
Saccharomyces cerevisiae
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
all-trans-beta-carotene + O2
-
744574
Saccharomyces cerevisiae ULI3
all-trans-10'-apo-beta-carotenal + beta-ionone
-
-
-
?
alpha-carotene + O2
-
744574
Saccharomyces cerevisiae
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
-
?
alpha-carotene + O2
-
744574
Saccharomyces cerevisiae ULI3
beta-apo-10'-carotenal + alpha-apo-10'-carotenal
-
-
-
?
lutein + O2
-
744574
Saccharomyces cerevisiae
?
-
-
-
?
lutein + O2
-
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
?
additional information
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
744574
Saccharomyces cerevisiae
?
-
-
-
-
additional information
enzyme ScBCO2 only exhibits cleavage activity towards carotenoid substrates containing two beta-ionone rings and its catalytic efficiency (kcat/Km) follows the descending order beta-carotene, alpha-carotene, lutein
744574
Saccharomyces cerevisiae
?
-
-
-
-
additional information
ScBCO2-catalyzed conversion of beta-carotene to beta-apo-10'-carotenal is followed by HPLC and LC-MS
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
-
additional information
enzyme ScBCO2 only exhibits cleavage activity towards carotenoid substrates containing two beta-ionone rings and its catalytic efficiency (kcat/Km) follows the descending order beta-carotene, alpha-carotene, lutein
744574
Saccharomyces cerevisiae ULI3
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 50000, SDS-PAGE
Saccharomyces cerevisiae
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
45
-
-
Saccharomyces cerevisiae
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
25
65
activity range, profile overview
Saccharomyces cerevisiae
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0167
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
0.0392
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
0.0475
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
-
Saccharomyces cerevisiae
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7
9
50 % of the maximal activity at pH 7.0 and pH 9.0, 20% at pH 6.0 and pH 9.5
Saccharomyces cerevisiae
General Information
General Information
Commentary
Organism
physiological function
the enzyme converts beta-carotene to beta-apo-10'-carotenal, which is a precursor of the plant hormone strigolactone
Saccharomyces cerevisiae
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the enzyme converts beta-carotene to beta-apo-10'-carotenal, which is a precursor of the plant hormone strigolactone
Saccharomyces cerevisiae
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.159
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
0.817
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
1.284
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.159
-
lutein
pH 8.0, 45°C
Saccharomyces cerevisiae
0.817
-
alpha-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
1.284
-
all-trans-beta-carotene
pH 8.0, 45°C
Saccharomyces cerevisiae
Other publictions for EC 1.13.11.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745596
Guo
Ablation of beta,beta-caroten ...
Mus musculus
J. Nutr. Biochem.
46
74-82
2017
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745345
Dela Sena
Substrate specificity of puri ...
Gallus gallus, Homo sapiens
J. Biol. Chem.
291
14609-14619
2016
-
-
2
-
-
-
-
-
1
-
-
2
-
2
-
-
2
-
-
-
-
-
11
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
2
-
-
-
-
11
-
2
-
-
-
2
-
-
-
-
3
3
-
-
-
745753
Gong
Mitochondrial beta-carotene 9 ...
Homo sapiens
Mol. Cancer Res.
14
966-975
2016
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
2
3
3
2
-
-
744160
Kim
Tissue- and sex-specific effe ...
Mus musculus, Mus musculus C57BL/6
Arch. Biochem. Biophys.
572
11-18
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744161
Raghuvanshi
Cellular localization of ?-ca ...
Rattus norvegicus
Arch. Biochem. Biophys.
572
19-27
2015
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
744574
Wei
Purification and characteriza ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae ULI3
Biotechnol. Lett.
37
1993-1998
2015
3
1
-
-
-
-
5
3
-
5
-
8
8
4
-
-
1
-
-
-
1
-
10
1
1
1
-
3
1
1
-
-
-
-
-
3
1
-
-
-
-
-
-
5
-
3
-
5
-
8
8
-
-
1
-
-
1
-
10
1
1
1
-
3
1
1
-
-
-
1
1
-
3
3
744613
Jlali
Nutrigenetics of carotenoid m ...
Gallus gallus
Br. J. Nutr.
111
2079-2088
2014
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746290
Li
Inactivity of human beta,beta ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6
Proc. Natl. Acad. Sci. USA
111
10173-10178
2014
-
-
2
-
2
-
-
-
-
-
-
10
-
10
-
-
-
-
-
2
-
-
11
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
10
-
-
-
-
-
2
-
-
11
-
2
-
-
-
2
-
-
-
-
5
5
-
-
-
727965
Amengual
Two carotenoid-oxygenases cont ...
Mus musculus
J. Biol. Chem.
288
34081-34096
2013
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
728057
Liu
Carotenoid cleavage dioxygenas ...
Lotus japonicus
J. Exp. Bot.
64
1967-1981
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
727353
Lobo
BCDO2 acts as a carotenoid sca ...
Danio rerio, Homo sapiens
Development
139
2966-2977
2012
-
-
-
-
-
-
1
-
3
-
-
-
-
6
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
719151
Kim
Production of beta-apo-10'-car ...
Homo sapiens
Biotechnol. Lett.
33
1195-1200
2011
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
5
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
5
1
1
-
-
-
-
-
-
-
1
1
719438
Amengual
A mitochondrial enzyme degrade ...
Mus musculus
FASEB J.
25
948-959
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
728552
Amengual
Beta-carotene reduces body adi ...
Mus musculus
PLoS ONE
6
e20644
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
714616
Vage
A nonsense mutation in the bet ...
Ovis aries
BMC Genet.
11
10
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
720559
Ledger
Modified CAROTENOID CLEAVAGE D ...
Actinidia chinensis
New Phytol.
188
803-813
2010
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720702
Auldridge
Characterization of three memb ...
Arabidopsis thaliana
Plant J.
45
982-993
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
720152
Lindqvist
Cell type-specific expression ...
Homo sapiens
J. Histochem. Cytochem.
53
1403-1412
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719823
Schwartz
The biochemical characterizati ...
Arabidopsis thaliana
J. Biol. Chem.
279
46940-46945
2004
1
-
-
-
1
-
-
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719806
Kiefer
Identification and characteriz ...
Homo sapiens, Mus musculus
J. Biol. Chem.
276
14110-14116
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
8
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-